Oxygenative Amidation of Metal Carbynoids via Pd-Catalyzed Three-Component Reaction of Alcohols, Imines, and α-Bromo Diazoacetates.

A palladium-catalyzed oxygenative amidation of metal carbynoids via three-component reaction of α-bromo diazoacetates, alcohols, and imines is reported. This strategy enables the simultaneous formation of C═O and C-N bonds at the carbynoid center, affording a broad range of oxindole-derived oxalamides in good to high yields under mild conditions. Mechanistic studies confirm that the carbonyl oxygen originates from the alcohol. This efficient and versatile method expands the synthetic utility of metal carbynoids, with ongoing studies focus on its potential in biologically active molecule discovery.