RARE-seq: an inflection point in cfRNA liquid biopsy.

Trends Pharmacol Sci

Division of Solid Tumor Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA. Electronic address:

Published: September 2025


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Article Abstract

Historically, the clinical application of cell-free RNA (cfRNA) liquid biopsies has been limited by background noise. In a recent study, Nesselbush et al. developed a method for denoising cfRNA analysis, resulting in RARE-seq, a versatile liquid biopsy platform that enables transcriptomic profiling, and cancer detection and monitoring, unlocking the potential of this exciting analyte.

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http://dx.doi.org/10.1016/j.tips.2025.08.001DOI Listing

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