Edge-Aware Diffusion Segmentation Model with Hessian Priors for Automated Diaphragm Thickness Measurement in Ultrasound Imaging.

The thickness of the diaphragm serves as a crucial biometric indicator, particularly in assessing rehabilitation and respiratory dysfunction. However, measuring diaphragm thickness from ultrasound images mainly depends on manual delineation of the fascia, which is subjective, time-consuming, and sensitive to the inherent speckle noise. In this study, we introduce an edge-aware diffusion segmentation model (ESADiff), which incorporates prior structural knowledge of the fascia to improve the accuracy and reliability of diaphragm thickness measurements in ultrasound imaging. We first apply a diffusion model, guided by annotations, to learn the image features while preserving edge details through an iterative denoising process. Specifically, we design an anisotropic edge-sensitive annotation refinement module that corrects inaccurate labels by integrating Hessian geometric priors with a backtracking shortest-path connection algorithm, further enhancing model accuracy. Moreover, a curvature-aware deformable convolution and edge-prior ranking loss function are proposed to leverage the shape prior knowledge of the fascia, allowing the model to selectively focus on relevant linear structures while mitigating the influence of noise on feature extraction. We evaluated the proposed model on an in-house diaphragm ultrasound dataset, a public calf muscle dataset, and an internal tongue muscle dataset to demonstrate robust generalization. Extensive experimental results demonstrate that our method achieves finer fascia segmentation and significantly improves the accuracy of thickness measurements compared to other state-of-the-art techniques, highlighting its potential for clinical applications.