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Background Undiagnosed hypertension among young adults is a growing public health concern, contributing silently to long-term cardiovascular morbidity. This study aimed to determine the prevalence of undiagnosed hypertension (Stage 1-2, previously unrecognized) and to assess statistically significant associations with lifestyle risk factors in a community-based young adult population. Methods A community-based, cross-sectional study was conducted at Hazrat Bari Sarkar (HBS) Medical and Dental College, Islamabad, Pakistan, from January to December 2023. Using non-probability convenience sampling, 263 adults aged 18-35 years were recruited. The sample size was calculated based on an estimated 22% prevalence, a 95% confidence level, and a 5% margin of error. Data were collected using a structured questionnaire and standardized blood pressure (BP) measurements. BP was measured twice, five minutes apart, in the morning, after the participant was seated and rested for at least five minutes. BP was categorized using the 2017 ACC/AHA guidelines. Data were analyzed with IBM SPSS Statistics for Windows, Version 26 (released 2019; IBM Corp., Armonk, NY, USA), using Chi-square tests; p < 0.05 was considered significant. Prevalence estimates are reported with 95% confidence intervals (CIs). Results The prevalence of undiagnosed hypertension (Stage 1-2, previously undiagnosed) was 14.83% (95% CI: 10.8%-19.7%), while 14.07% (95% CI: 10.1%-18.9%) had elevated BP (pre-hypertensive range). Undiagnosed hypertension was significantly associated with age 25-30 years (p = 0.011), a sedentary lifestyle (p = 0.001), high salt intake (p = 0.018), obesity (p = 0.041), and smoking (p = 0.026). Although more females than males had undiagnosed hypertension (22 vs. 17 cases), this difference was not statistically significant (p = 0.076). Conclusion Undiagnosed hypertension is prevalent among young adults and significantly associated with modifiable lifestyle factors. Given the limitations of convenience sampling and the specific college-based setting, the findings may not fully generalize to all young adults. Future studies should use stratified or cluster sampling to improve representativeness. Early, targeted screening and lifestyle interventions are warranted in this population.
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http://dx.doi.org/10.7759/cureus.88426 | DOI Listing |
Chronic thromboembolic pulmonary hypertension (CTEPH) is a rare but serious disease caused by persistent thromboembolic obstruction or narrowing of the pulmonary arteries. Its prevalence varies, and many cases remain undiagnosed, contributing to a substantial clinical burden. This study aimed to summarize all CTEPH cases diagnosed in Latvia in 2024, calculate the annual incidence, and present additional epidemiological data from Latvian pulmonary hypertension (PH) registry.
View Article and Find Full Text PDFCureus
August 2025
Department of Obstetrics and Gynecology, Ministry of National Guard Health Affairs, Riyadh, SAU.
This case report discusses the overall care of a female patient with nephrotic syndrome secondary to non-pre-eclampsia-related hypertension in pregnancy, emphasizing the challenges and multidisciplinary treatment needed for desired results. The case presented here involves a 32-year-old pregnant woman with a history of unexplained primary infertility who conceived through in vitro fertilization (IVF). At 26 weeks and three days of gestation, she presented with symptoms suggestive of nephrotic syndrome, including lower limb swelling, facial puffiness, oliguria, and dark-colored urine.
View Article and Find Full Text PDFHipertens Riesgo Vasc
September 2025
Cardiology Department, Santa Lucía University Hospital, Cartagena, Spain.
Patient with classic cardiovascular risk factors under treatment and apparently well controlled, with good adherence to the treatment, but with repeated acute coronary syndromes. After investigating these risk factors, arterial hypertension secondary to undiagnosed sleep apnoea-hypopnoea syndrome was detected. In addition, the patient's residual risk was addressed, prescribing treatment for his atherogenic dyslipidaemia and, in addition, elevated levels of lipoprotein (a) were discovered.
View Article and Find Full Text PDFJAMA Cardiol
September 2025
Department of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota.
Importance: Sleep disordered breathing (SDB) is a well-established contributor to cardiovascular morbidity, mediated by intermittent hypoxemia, autonomic dysregulation, and endothelial dysfunction. Patients with hypertrophic cardiomyopathy (HCM) may be especially at risk for SDB, but the clinical impact of SDB in this population remains unclear.
Objective: To define the prevalence and subtypes of SDB in HCM and examine their association with echocardiographic parameters and cardiac biomarker expression.
Scand J Clin Lab Invest
September 2025
Division of Clinical Chemistry and Pharmacology, Department of Laboratory Medicine, Lund University, Lund, Sweden.
Cystatin C was identified as a marker of glomerular filtration rate (GFR) in 1979, and the parallel analysis of cystatin C and creatinine led to the identification of shrunken pore syndrome (SPS) - a new kidney disorder - in 2015. Since then, it has been shown that cystatin C in many aspects is superior to creatinine as a marker of GFR and cardiovascular risk. SPS, an entity within the selective glomerular hypofiltration syndromes (SGHS), has been demonstrated to be associated with a strong increase in morbidity and mortality in several populations.
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