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Capgras syndrome (CS) presents a unique diagnostic and management challenge, particularly when associated with neurodegenerative conditions. This case report describes a 73-year-old female diagnosed with Lewy body dementia (LBD) who developed CS, manifesting as the delusional belief that her deceased husband had been replaced by an imposter. The clinical presentation was complex, including pronounced sleep disturbances, cognitive decline, behavioral anomalies, and visual hallucinations, necessitating a thorough differential diagnosis process. We detail the patient's history, clinical findings, and the investigations undertaken, including brain imaging and cognitive assessments. The management approach involved a personalized treatment plan integrating Lithium sulfate, Citalopram, and Lurasidone, alongside psychosocial interventions. While a partial improvement was observed, the case underscores the complexities of managing CS in the context of LBD, highlighting the need for tailored and multidisciplinary approaches to care. This case contributes to the limited literature on CS in LBD and provides practical insights for clinicians managing similar presentations.
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http://dx.doi.org/10.1155/crps/5541100 | DOI Listing |
Case Rep Psychiatry
August 2025
Saint Camillus International University of Health and Medical Sciences, Via di Sant'Alessandro 8, Rome 00131, Italy.
Capgras syndrome (CS) presents a unique diagnostic and management challenge, particularly when associated with neurodegenerative conditions. This case report describes a 73-year-old female diagnosed with Lewy body dementia (LBD) who developed CS, manifesting as the delusional belief that her deceased husband had been replaced by an imposter. The clinical presentation was complex, including pronounced sleep disturbances, cognitive decline, behavioral anomalies, and visual hallucinations, necessitating a thorough differential diagnosis process.
View Article and Find Full Text PDFBMC Psychiatry
August 2025
Faculty of Medicine, Department of Psychiatry, Giresun University, Giresun, Turkey.
Background: Capgras syndrome (CS) is a rare delusional disorder characterized by the delusional belief that a relative has been replaced by an identical person. This syndrome is frequently associated with psychotic disorders and neurological diseases.
Case Presentation: In this case report, we describe a 42-year-old woman who developed Capgras syndrome following a severe upper respiratory tract infection.
Brain Sci
June 2025
Neurocenter, Swiss Medical Network, Clinique Valmont, Montreux, Switzerland.
Striking belief distortions may accompany various disorders of awareness that are predominantly associated with right hemispheric cerebral dysfunction. Distortions may range on a continuum of pathological severity, from the unawareness of paralysis in anosognosia for hemiplegia, to a more startling disturbance in denial of paralysis where belief may starkly conflict with reality. The patients' beliefs about their limitations typically represent attempts to make sense of limitations or to impart meaning to incongruous facts.
View Article and Find Full Text PDFGeriatr Psychol Neuropsychiatr Vieil
June 2025
Gerontopôle, Inserm U1027, Alzheimer's Disease Research and Clinical Center, Toulouse University Hospital, France.
Dementia with Lewy bodies (DLB) and Parkinson's disease dementia (PDD) have frequent psychological and behavioral symptoms (PBS). Treatment of these PBS is variably validated We carried out a review of the treatment of PBS in DLB and PDD from 2009 to 2023. Where the literature allowed, we made treatment recommendations.
View Article and Find Full Text PDFCase Rep Psychiatry
May 2025
Department of Neuropsychiatry, Oita University Faculty of Medicine, Yufu, Oita, Japan.
Delusional misidentification syndromes (DMSs) are a group of disorders, characterized by consistent misidentification of individuals, locations, objects, or events. Four primary subtypes are recognized within this classification: Capgras syndrome, Frégoli syndrome, intermetamorphosis syndrome, and the syndrome of subjective doubles. We report a case of a woman with schizophrenia who experienced a strange delusion that her parents were her babies.
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