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After total hip replacement, the primary and secondary implant stability is critical to ensure long-term success. Excessive migration of the femoral stem can cause implant loosening. In this work, a novel approach for the simulation of the femoral stem migration using the finite element method is presented. Currently, only a few mostly contact-based models exist for this purpose. Instead, a bio-active interface model is used for the bone-stem interface which transforms from the Drucker-Prager to the von Mises plasticity criterion during the osseointegration process. As the position of the implant generally stabilises within one week after the implantation, the migration and osseointegration simulations are decoupled. To understand the effects on the migration, various parameter combinations are examined and a sensitivity analysis is performed. The results indicate that the joint force and the adhesion parameter have the most substantial influence on the migration. Furthermore, the influence of the migration on the subsequent osseointegration process is explored for a numerical example. The proposed model is able to depict the femoral stem migration with values up to 0.27 mm, which are in the order of magnitude of clinically observed values. Further, the model is provided as an open-source Abaqus user material subroutine. Numerical simulation of the stem migration could assist in clinical decision-making by identifying optimal parameter combinations to improve implant stability.
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http://dx.doi.org/10.1007/s10237-025-01985-0 | DOI Listing |
Neurosci Biobehav Rev
September 2025
Instituto de Neurobiología, Universidad Nacional Autónoma de México.
Epigenetic mechanisms are essential in neurogenesis during development and adulthood. DNA methylation, histone post-translational modifications, and non-coding RNAs regulate gene expression to maintain the neural stem cell pool and direct the fate of newborn neurons by modulating cell proliferation, migration, differentiation, maturation, and survival. Adult neurogenesis exhibits bidirectional interactions with non-social and socio-sexual factors such as sexual behavior, mate recognition, pair bonding, parental behavior, and offspring recognition.
View Article and Find Full Text PDFFASEB J
September 2025
Department of Biosciences, Rice University, Houston, Texas, USA.
The enteric nervous system (ENS) is the intrinsic nervous system of the gut and controls essential functions, such as gut motility, intestinal barrier function, and water balance. The ENS displays a complex 3D architecture within the context of the gut and specific transcriptional states needed to control gut homeostasis. During development, the ENS develops from enteric neural progenitor cells (ENPs) that migrate into the gut and differentiate into functionally diverse neuron types.
View Article and Find Full Text PDFCurr Mol Med
August 2025
Department of Biochemistry, Dow International Medical College, Dow University of Health Sciences, OJHA Campus, Karachi, Pakistan.
Introduction: Glioblastoma multiforme (GBM) is a highly aggressive brain tumor with a poor prognosis, primarily due to therapy resistance mediated by CD133+ glioblastoma stem cells (GSCs). The BCL3 gene contributes to this resistance and is potentially regulated by Carbonic Anhydrase II (CA II). Additionally, BCL3 enhances β-catenin-mediated transcription, promoting tumor growth.
View Article and Find Full Text PDFFASEB Bioadv
August 2025
Laboratory of Molecular Signaling and Stem Cells Therapy, Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction Beijing Stomatological Hospital, School of Stomatology, Capital Medical University Beijing China.
Previous studies reported the pro-osteogenic ability of L-Tryptophan (L-Trp) and Calcium-Sensing RCeceptor (CaSR) respectively. Recent researchers found L-Trp could activate CaSR. Therefore, this study investigated the osteogenic mechanisms of L-Trp through CaSR activation.
View Article and Find Full Text PDFNeural crest cells (NCCs) are a multipotent cell population that undergo specification, epithelial-to-mesenchymal transition, migration, and differentiation into a plethora of cell types. A wealth of studies across various embryonic model systems have established dogma as to the molecular mechanisms and signaling cascades that contribute to NCC development. While Wnt, FGF, and BMP signaling pathways have well-established and essential roles in several aspects of NCC development, the Hedgehog (HH) signaling pathway has received limited attention for any specific role in this process.
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