Pilot Study: Improving Glycemic Control Among Children and Adolescents With Obesity and Prediabetes With Real-Time Feedback Via Continuous Glucose Monitoring.

Objective: To assess the feasibility and efficacy of a novel use of continuous glucose monitoring (CGM) in prediabetes to promote behavioral change and improve glycemia.

Research Design And Methods: We conducted a single-arm prospective study in a pediatric obesity clinic to evaluate the feasibility and acceptability of wearing a CGM sensor in children aged 10-17 years with obesity (BMI ≥95th percentile for age) and prediabetes. Feasibility was determined through participant recruitment. We analyzed differences in A1C, glucose variability, BMI, and dietary intake at 12 weeks.

Results: Of 22 participants recruited, 14 completed the study. Over 12 weeks, the mean BMI percentage of the 95th percentile decreased from 153.4 to 150.1% ( = 0.006), daily estimated carbohydrate consumption decreased by 41.4% ( = 0.009), and A1C decreased by 0.2% ( = 0.03).

Conclusion: CGM in an adolescent population with prediabetes and obesity may be a helpful adjunct to therapy to improve A1C, support dietary changes, reduce the rate of weight gain, and attenuate diabetes risk.