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Epidermoid inclusion cysts are benign lesions resulting from implantation and proliferation of epidermal elements within the dermis, often following trauma and surgery. They are rare in penile region, especially in pediatric patients. This report describes a four-year-old boy who experienced a painless swelling of the penile foreskin two years after undergoing traditional circumcision. Clinical examination revealed a mobile mass on the ventral aspect of the foreskin. Surgical excision, as well as circumcision, were performed under general anesthesia, and histopathology confirmed the diagnosis. The patient recovered after surgery, with no recurrence.
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http://dx.doi.org/10.1016/j.eucr.2025.103151 | DOI Listing |
J Nippon Med Sch
September 2025
Department of Urology, Nippon Medical School.
Background: Current guidelines lack recommendations for serum tumor markers in patients with upper tract urothelial carcinoma (UTUC) undergoing radical nephroureterectomy (RNU). This study assessed the potential of the postoperative serum C-terminus of cytokeratin 19 (CYFRA21-1, CYFRA) level, hereafter referred to as poCY, as a predictor of early progression in patients treated with RNU.
Methods: Overall, 117 patients were categorized into the high group (HG) or low group (LG) based on a poCY cutoff level of 3.
Drug Metab Rev
September 2025
Department of Chemistry, Faculty of Science, Sri Chandrasekharendra Saraswathi Viswa Mahavidyalaya (Deemed to be University) (SCSVMV), Kanchipuram, India.
This comprehensive review explores the therapeutic promise of cyclodextrin-grafted magnetite (FeO) nanocarriers in anticancer applications, focusing on their design, drug delivery mechanisms, biological stability, and therapeutic performance. Systems integrating cyclodextrins (cds) with FeO nanoparticles (FeO-cd-drug) have been developed for delivery of key anticancer agents such as docetaxel, irinotecan, paclitaxel, and doxorubicin across 11 cancer cell types. Results demonstrate up to 60% reduced cancer cell viability when using magnetite nanoparticle (FeO-np)-cds-docetaxel/irinotecan/doxorubicin systems compared to the pristine drug.
View Article and Find Full Text PDFDrug Deliv Transl Res
August 2025
Department of Industrial Pharmacy, Faculty of Pharmacy, Alexandria University, 1 El Khartoum Square, PO Box 21521, Alexandria, Egypt.
Biopolymer-based composite films were primed by incorporating alginate and zein natural polymers using a solution-casting method and superbly assisted by eco-friendly prepared copper oxide nanoparticles (CuO NPs). The influence of the addition method of CaCl as a crosslinker and CuO NPs loading content (0.1, 0.
View Article and Find Full Text PDFInt J Gynaecol Obstet
July 2025
Pathology Department, La Paz University Hospital, Madrid, Spain.
Craniopharyngiomas are the most common non-neuroepithelial intracerebral neoplasms in children but rarely occur before birth, and are typically associated with a poor prognosis. We present the case of a 39-year-old woman with a spontaneously conceived singleton pregnancy. At 20 weeks of gestation, ultrasound detected a 44×25 mm heterogeneously hyperechogenic intracranial mass located at the base of the sphenoid bone, extending bilaterally.
View Article and Find Full Text PDFFront Immunol
August 2025
Inflammatory Immune-Mediated Chronic Skin Diseases Laboratory, Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Córdoba, Spain.
Unlabelled: Primary lymphocytic scarring alopecias (PLSAs)-including frontal fibrosing alopecia (FFA), lichen planopilaris (LPP), and central centrifugal cicatricial alopecia (CCCA)-are chronic inflammatory scalp disorders leading to irreversible follicular destruction. Despite overlapping histopathology, their molecular differences remain poorly defined. We performed the first systematic review and transcriptomic meta-analysis of human scalp biopsies in PLSAs (PROSPERO: CRD42024559969), following PRISMA 2020 guidelines.
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