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is an emerging pathogen in human beings and only a few clinical cases were reported in the literature. We detected the presence of this unusual microbe among the skin flora of three patients with filarial lymphedema in a 16S rRNA-based metagenomic study on the skin microbiome. To our knowledge, this is the first report of detection of this microbe in patients affected with filarial lymphedema. Further investigations are required to elucidate the role of in secondary skin and soft tissue infection of filarial lymphedema patients.
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http://dx.doi.org/10.3389/fcimb.2025.1624288 | DOI Listing |
PLoS Negl Trop Dis
September 2025
Unit of Clinical and Molecular Medicine, ICMR-Vector Control Research Centre (VCRC), Indira Nagar, Puducherry, India.
Background: Filarial lymphedema, caused by lymphatic filariasis, is characterized by chronic swelling and recurrent skin infections. Acute adenolymphangitis (ADL) episodes significantly exacerbate morbidity. Diabetes mellitus (DM) increases susceptibility to infections; however, the relationship between diabetes and ADL frequency and severity in filarial lymphedema patients remains unclear.
View Article and Find Full Text PDFPLoS Negl Trop Dis
September 2025
Institute of Immunology & Infection Research, University of Edinburgh, Ashworth Laboratories, Edinburgh, United Kingdom.
Background: Neglected tropical diseases (NTDs) are a group of 21 diseases affecting approximately 1.5 billion people globally. Significant progress has been made in their control: by March 2024, 50 countries had eliminated at least one NTD, with 13 of these countries eliminating at least two.
View Article and Find Full Text PDFClin Exp Dermatol
September 2025
Children's Investment Fund Foundation, Addis Ababa, Ethiopia.
Podoconiosis, a neglected tropical disease, manifests as non-filarial lymphedema, primarily affecting the lower limbs. It arises due to prolonged exposure of bare feet to irritant red clay soils in genetically susceptible individuals. The disease is preventable and manageable but remains a public health challenge in endemic areas, including several countries in Africa, Asia, and Latin America.
View Article and Find Full Text PDFFront Cell Infect Microbiol
August 2025
Unit of Clinical and Molecular Medicine, ICMR-Vector Control Research Centre, Puducherry, India.
is an emerging pathogen in human beings and only a few clinical cases were reported in the literature. We detected the presence of this unusual microbe among the skin flora of three patients with filarial lymphedema in a 16S rRNA-based metagenomic study on the skin microbiome. To our knowledge, this is the first report of detection of this microbe in patients affected with filarial lymphedema.
View Article and Find Full Text PDFPLoS Negl Trop Dis
August 2025
Liverpool School of Tropical Medicine, Liverpool, United Kingdom.
Background: Neglected tropical diseases (NTDs) such as lymphatic filariasis (LF) are a significant concern in developing countries like Bangladesh. Understanding the health and social needs of individuals with LF is essential for improving their healthcare-seeking experiences and advancing the health system's capacity. Therefore, this qualitative study aimed to explore the social and care-seeking experiences of persons with LF in Bangladesh.
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