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Background: Irreparable rotator cuff tears (IRCTs) pose a clinical challenge, particularly in younger patients. Tendon transfers (TTs) have emerged as a joint-preserving surgical option. However, the clinical outcomes, failure rates, and complication profiles associated with different TTs remain incompletely defined. This systematic review evaluates outcomes across various TT techniques used to manage IRCTs.
Methods: A systematic search of MEDLINE, Embase, and Emcare databases was conducted for studies involving adults with diagnosed IRCTs reporting patient-reported outcomes and failure rates following TT. Non-English studies, conference abstracts, case reports, and studies with <12 months follow-up were excluded. Descriptive summaries and pooled analyses were performed by tendon type.
Results: Thirty studies (980 patients, 994 shoulders) were included. The mean patient age was 58.9 years, with a mean follow-up of 44.7 months. Latissimus dorsi (LD) transfers were most commonly reported. All tendon types showed significant improvements in patient-reported outcomes. Teres major transfers exhibited the highest Constant-Murley Score improvement (+40) and greatest pain reduction (VAS-5.6), although based on a single study. Failure rates ranged from 4.2% to 14.1%.
Conclusions: TTs improve pain and function in IRCTs. LD transfers remain the most widely used. Variability in techniques and outcomes highlights the need for standardized protocols and further high-quality research.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12354401 | PMC |
http://dx.doi.org/10.1177/17585732251368884 | DOI Listing |
Retina
September 2025
School of Mathematical and Computational Sciences, University of Prince Edward Island, Charlottetown, Canada.
Purpose: Systemically administered anti-cancer VEGF inhibiting therapies can cause severe kidney injury. Intravitreal aflibercept has a greater impact on renal VEGF levels than ranibizumab. We compared the risk of kidney injury among patients receiving intravitreal aflibercept vs.
View Article and Find Full Text PDFACS Nano
September 2025
Department of Emergency and Critical Care Medicine, The Fourth Affiliated Hospital of Soochow University, Suzhou 215124, China.
Acute lung injury (ALI) is characterized by the excessive accumulation of reactive oxygen species (ROS), which triggers a severe inflammatory cascade and the destruction of the alveolar-capillary barrier, leading to respiratory failure and life-threatening outcomes. Considering the limitations and adverse effects associated with current therapeutic interventions, developing effective and safe strategies that target the complex pathophysiological mechanisms of ALI is crucial for improving patient outcomes. Herein, we developed an inhalable, multifunctional nanotherapeutic (MSCNVs@CAT) by encapsulating catalase (CAT) in mesenchymal-stem-cell-derived nanovesicles (MSCNVs).
View Article and Find Full Text PDFPLoS One
September 2025
University of Health and Allied Sciences, Volta Region-Ho, Ghana.
Introduction: The alarming rate of drug-resistant tuberculosis (DR-TB) globally is a threat to treatment success among positive tuberculosis (TB) cases. Studies aimed at determining the prevalence, trend of DR-TB and socio-demographic and clinical risk factors contributing to DR-TB in the four regions of Ghana are currently unknown. This study sought to determine the prevalence and trend of DR-TB, identify socio-demographic and clinical risk factors that influence DR-TB, and analyse the relationship between underweight and adverse drug reactions and treatment outcomes among DR-TB patients in four regions of Ghana.
View Article and Find Full Text PDFPLoS One
September 2025
Department of Cardiology, Fuzhou University Affiliated Provincial Hospital, Fujian Provincial Hospital, Fuzhou, Fujian, China.
Introduction: Kidney stone disease is associated with numerous cardiovascular risk factors. However, the findings across studies are non-uniformly consistent, and the control of confounding variables remains suboptimal. This study aimed to investigate the association between kidney stone and cardiovascular disease.
View Article and Find Full Text PDFJ Am Podiatr Med Assoc
September 2025
§Aybars Kıvrak Orthopedics Clinic, Adana, Turkey.
Background: Pilon fractures refer to distal tibial fractures that may involve extra-articular, partial articular, or complete intra-articular components, most commonly caused by high-energy trauma. The choice between early (<72 hours) and delayed (>7 days) surgical fixation significantly impacts clinical outcomes. This study aimed to compare the effects of early vs.
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