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Unlabelled: Sequential data is ubiquitous-it is routinely gathered to gain insights into complex processes such as behavioral, biological, or physical processes. Challengingly, such data not only has dependencies within the observed sequences, but the observations are also often high-dimensional, sparse, and noisy. These are all difficulties that obscure the inner workings of the complex process under study. One solution is to calculate a low-dimensional representation that describes (characteristics of) the complex process. This representation can then serve as a proxy to gain insight into the original process. However, uncovering such low-dimensional representation within sequential data is nontrivial due to the dependencies, and an algorithm specifically made for sequences is needed to guarantee estimator consistency. Fortunately, recent theoretical advancements on Block Markov Chains have resulted in new clustering algorithms that can provably do just this in synthetic sequential data. This paper presents a first field study of these new algorithms in real-world sequential data; a wide empirical study of clustering within a range of data sequences. We investigate broadly whether, when given sparse high-dimensional sequential data of real-life complex processes, useful low-dimensional representations can in fact be extracted using these algorithms. Concretely, we examine data sequences containing GPS coordinates describing animal movement, strands of human DNA, texts from English writing, and daily yields in a financial market. The low-dimensional representations we uncover are shown to not only successfully encode the sequential structure of the data, but also to enable gaining new insights into the underlying complex processes.
Supplementary Information: The online version contains supplementary material available at 10.1007/s10618-025-01140-4.
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http://dx.doi.org/10.1007/s10618-025-01140-4 | DOI Listing |
Int J Cosmet Sci
September 2025
Smart Foods and Bioproducts, AgResearch, Lincoln, New Zealand.
Objective: This study investigated the locations of amino acid modifications within two major human hair keratins (Type I K31 and Type II K85) with probable implications for protein and hair structural component integrity. The particular focus was on cysteine modifications that disrupt intra-protein and inter-protein disulphide bonds.
Methods: Human hair was exposed to accelerated, sequential heat or UV treatments, simulating effects resulting from the use of heated styling tools and environmental exposure over a time frame approximating one year.
J Appl Stat
February 2025
RBS, International University of Rabat, Technopolis, Sala-Al-Jadida, Morocco.
The paper first highlights important drawbacks and biases related to the common use of time-rescaling to assess the goodness-of-fit (Gof) of self-exciting temporal point process (SETPP) models. Then it presents a new predictive time-rescaling approach leading to an asymptotically unbiased Gof framework for general SETPPs in the case of single observed trajectories. The predictive approach focuses on forecasting accuracy and addresses the bias problem resulting from the plugged-in estimated parameters.
View Article and Find Full Text PDFBackground: Adolescents with autism spectrum disorder (ASD) often experience identity confusion, social difficulties, and internalizing symptoms such as anxiety and depression. Physical activity offers opportunities for peer interaction and teamwork, which may help alleviate negative emotions. This study aims to investigate the pathways through which physical activity influences internalizing problems in adolescents with ASD.
View Article and Find Full Text PDFFront Med (Lausanne)
August 2025
Department of Health Sciences, University of York, York, United Kingdom.
Introduction: Simulation-Based Teaching (SBT) has emerged as an educational strategy to enhance clinical competence among medical students, particularly in Gynaecology and Obstetrics.
Objective: This study assessed the effectiveness of learning SBT and explored the enablers and challenges associated with implementing SBT in Gynaecology and Obstetrics.
Methods: Using a sequential explanatory mixed methods approach a study was conducted in Skills Lab at Pakistan Emirates Military Hospital (PEMH), Rawalpindi during May-Sep 2024.
Cureus
August 2025
Department of Urology, The Institute of Medical Science, The University of Tokyo, Tokyo, JPN.
In patients with advanced urothelial carcinoma who have progressed after platinum-based chemotherapy, enfortumab vedotin (EV) improves overall survival compared to standard chemotherapy. Additionally, for treatment-naïve patients with locally advanced or metastatic urothelial carcinoma, the combination of pembrolizumab and EV demonstrates superior efficacy over platinum-based chemotherapy. Hence, EV becomes a standard treatment option.
View Article and Find Full Text PDF