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http://dx.doi.org/10.1016/j.jns.2025.123656 | DOI Listing |
J Affect Disord
September 2025
Department of Neurology, The First Affiliated Hospital of Guangxi University of Chinese Medicine, Guangxi University of Chinese Medicine, Nanning, 530023, PR China. Electronic address:
Objective: Major depressive disorder (MDD) is among the most prevalent and debilitating mental health conditions worldwide. This study aims to investigate the bidirectional causal relationship between immune cells and MDD using Mendelian randomization (MR) analysis and determine whether metabolites mediate this relationship.
Methods: We compiled and analyzed whole-genome data for 731 immune cell traits, 1091 blood metabolites, 309 metabolic ratios, and disease data from 170,756 individuals with MDD and 329,443 controls.
J Environ Manage
September 2025
University of Maryland Center for Environmental Science, Annapolis, MD, USA.
River water quality degradation is a prevailing problem in coastal China with intensifying human-nature interaction. However, the spatial and temporal dynamics of water quality and their drivers remain poorly understood. In this study, we developed an analytical framework integrating self-organizing mapping (SOM) with partial least squares structural equation models (PLS-SEMs) to analyze the patterns and drivers of river water quality at 49 stations from 2021 to 2023 in Fujian Province, a coastal region in southeastern China.
View Article and Find Full Text PDFDriven by eutrophication and global warming, the occurrence and frequency of harmful cyanobacteria blooms (CyanoHABs) are increasing worldwide, posing a serious threat to human health and biodiversity. Early warning enables precautional control measures of CyanoHABs within water bodies and in water works, and it becomes operational with high frequency in situ data (HFISD) of water quality and forecasting models by machine learning (ML). However, the acceptance of early warning systems by end-users relies significantly on the interpretability and generalizability of underlying models, and their operability.
View Article and Find Full Text PDFCancer Metastasis Rev
September 2025
Department of Periodontics and Oral Medicine, University of Michigan School of Dentistry, 1011 North University Ave, Room G018, Ann Arbor, MI, 48109-1078, USA.
Chronic inflammation and microbial dysbiosis have been implicated in the development of head and neck squamous cell carcinoma (HNSCC), particularly oral cavity squamous cell carcinoma (OSCC). Periodontitis is a common chronic inflammatory disease characterized by the progressive destruction of tooth-supporting structures. While periodontitis Has been associated with an increased risk of OSCC in epidemiological and mechanistic studies, the strength of this association is unclear.
View Article and Find Full Text PDFMol Biol Rep
September 2025
ICAR-Central Institute of Fisheries Education, Versova, Mumbai, 400061, India.
Background: Labeo fimbriatus (Bloch, 1795) is a medium-sized South Asian minor carp with ecological significance and emerging aquaculture potential, particularly in polyculture systems with Indian major carps. Despite its wide distribution, it remains underrepresented in phylogenetic studies, and limited genomic resources are available. Here, we report the complete mitochondrial genome sequence of L.
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