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Unlabelled: Allergy in children is increasing. Reactions vary, with severe cases involving potentially fatal anaphylaxis which is treated with adrenaline. At-risk patients are prescribed adrenaline auto-injectors. However, due to limited specialist UK allergy clinics, risk discussions often take place with non-specialists (e.g., General Practitioners in primary care and general paediatricians in secondary care) who may lack confidence discussing risk and determining treatment suitability. Systematic examination of strategies for discussing risk is needed.
Objectives: To identify, for the first time, strategies for communicating risk and negotiating adrenaline auto-injector prescribing decisions in actual paediatric allergy consultations.
Methods: We examined 23 video-recorded consultations in the U.K., involving one consultant paediatric allergy specialist, 23 patients (age 2-10) and caregivers. We identified 11 risk discussions, applying the rigorous method of conversation analysis to explicate practices for communicating risk of anaphylaxis and reaching adrenaline auto-injector prescription decisions. Data in British English.
Results: Our novel and detailed findings demonstrate risk communication via categories such as low, moderate, and high risk, animated with gestures, explained with reassuring and worrying factors, and with reference to caregiver anxiety. However, risk assessments were tempered by raising uncertainty - concerns around the quality of the medical evidence. Further, severity of risk was carefully modified, individually tailored to each interactional context.
Conclusions: Our findings offer significant and new insights into how expert knowledge can be made available to patients/caregivers. Reasoning around risk was made explicit when adrenaline auto-injectors were proposed but not "pushed." This practice levelled each party's access to knowledge, flattening the epistemic gradient between doctor and patient/caregiver. As such patient/caregiver input in collaborative decision-making is facilitated.
Practice Implications: Our findings offer specific, nuanced, and contextualised communication practices for conveying risk from an experienced specialist. These are available to significantly contribute to practice/education toolkits aimed at nonspecialists and those practising infrequently in this area.
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http://dx.doi.org/10.1016/j.pec.2025.109284 | DOI Listing |
J Eval Clin Pract
September 2025
Cochrane Taiwan, Taipei Medical University, Taipei, Taiwan.
Background: Chest radiography is often performed preoperatively as a common diagnostic tool. However, chest radiography carries the risk of radiation exposure. Given the uncertainty surrounding the utility of preoperative chest radiographs, physicians require systematically developed recommendations.
View Article and Find Full Text PDFPharmacotherapy
September 2025
Department of Biomedical Informatics, School of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Background: Omeprazole, a widely used proton pump inhibitor, has been associated with rare but serious adverse events such as myopathy. Previous research suggests that concurrent use of omeprazole with fluconazole, a potent cytochrome P450 (CYP) 2C19/3A4 inhibitor, may increase the risk of myopathy. However, the contribution of genetic polymorphisms in CYP enzymes remains unclear.
View Article and Find Full Text PDFGenet Med
September 2025
Division of Medical Genetics, University of Washington School of Medicine.
Purpose: The fourth phase of the Electronic Medical Records and Genome Network (eMERGE4) is testing the return of 10 polygenic risk scores (PRS) across multiple clinics. Understanding the perspectives of health-system leaders and frontline clinicians can inform plans for implementation of PRS.
Methods: Fifteen health-system leaders and 20 primary care providers (PCPs) took part in semi-structured interviews.
J Magn Reson Imaging
September 2025
Department of Neurology, Dell Medical School, University of Texas at Austin, Austin, Texas, USA.
Background: Cerebrovascular reactivity reflects changes in cerebral blood flow in response to an acute stimulus and is reflective of the brain's ability to match blood flow to demand. Functional MRI with a breath-hold task can be used to elicit this vasoactive response, but data validity hinges on subject compliance. Determining breath-hold compliance often requires external monitoring equipment.
View Article and Find Full Text PDFMult Scler
September 2025
Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA.
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Objective: A GWAS was performed to identify variants associated with TD.