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In this Opinion, the authors investigated peer-reviewed publications on alpha-gal syndrome (AGS), also known as red meat allergy, since its first description in the literature in 2009 to October 2024 to understand academic discipline and geographic affiliation of associated authors. We raise the issue of disproportionate contribution between medical disciplines and ecology/entomology disciplines and emphasize the positive future impacts of increased collaboration between the fields to address current gaps in our fundamental knowledge of this unique tick-borne disease.
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http://dx.doi.org/10.1016/j.ttbdis.2025.102538 | DOI Listing |
Pathogens
August 2025
Departamento de Microbiología y Parasitología, Facultad de Farmacia, Universidad Complutense de Madrid, 28040 Madrid, Spain.
This study investigates the potential of sp. as a novel source of α-Gal (Galα1-3Galβ1-4GlcNAc-R) epitopes capable of inducing allergic sensitization in humans. While α-Gal is classically associated with delayed IgE-mediated hypersensitivity following tick bites, emerging evidence suggests that parasitic helminths such as sp.
View Article and Find Full Text PDFHead Neck
August 2025
Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Background: Alpha-gal syndrome is an allergic condition resulting from the bite of the Lonestar tick in the southeastern US that leads to sensitization to mammalian products containing the oligosaccharide galactose-alpha-1,3-galactose (alpha-gal). Cetuximab is a chimeric monoclonal antibody that contains alpha-gal and can lead to allergic reactions in individuals with alpha-gal syndrome.
Methods: A 66-year-old with metastatic squamous cell carcinoma of the right tonsil with involvement of the lung and liver was planned to receive palliative therapy with cetuximab.
Ann Allergy Asthma Immunol
August 2025
University of Missouri Department of Dermatology, 1 Hospital Drive MA 111, Columbia, MO, 65212. Electronic address:
Cureus
July 2025
Internal Medicine, Howard University Hospital, Washington, DC, USA.
Background Mammalian meat allergy (MMA), increasingly linked to delayed hypersensitivity reactions such as alpha-gal syndrome, is a growing public health concern. This study evaluates the incidence, prevalence, and incidence rate of MMA in a large, diverse population of over 114 million individuals across two time periods (2015-2020 and 2021-2025), with stratification by age, sex, race, and ethnicity. Methods Using longitudinal electronic health record data, we calculated incidence proportion, prevalence, and incidence rate (cases per person-day) for MMA diagnoses.
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May 2025
Department of Biochemistry, Sri Manakula Vinayagar Medical College and Hospital, Kalitheerthalkuppam, Madagadipet, Puducherry, India.
A 31-year-old female presented with complaints of itching with previous history of 5-6 anaphylactic reactions since last one month. Her symptoms were preceded (3-6 hours) with intake of red meat. She suffered one tick bite (probably a lone star tick) one month before the allergic episodes.
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