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FluMag-SELEX derived specific individual aptamers can fluorescently label the ageing immanent protein-crosslinker glucosepane in diabetic mouse tissues. | LitMetric
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FluMag-SELEX derived specific individual aptamers can fluorescently label the ageing immanent protein-crosslinker glucosepane in diabetic mouse tissues.

Runliu Li , Bastian Draphoen , Mika Lindén , Karmveer Singh , Karin Scharffetter-Kochanek , Andreas Stürmer , Frank Rosenau , Ann-Kathrin Kissmann

Nanoscale Horiz

Institute of Pharmaceutical Biotechnology, Ulm University, Albert-Einstein-Allee 11, 89081 Ulm, Germany.

Published: August 2025

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Article Abstract

Nowadays, aptamers have transitioned into valuable antibody alternatives. We present the first anti-glucosepane aptamer targeting a key glycation product linked to aging and diabetes. Glu3, with high specificity and affinity, enabled the first-ever direct, fluorescence-based histological staining of glucosepane in murine tissue, distinguishing diabetic samples from wild-type samples without secondary reagents.

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 Source
http://dx.doi.org/10.1039/d5nh00263jDOI Listing

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