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Article Abstract
X chromosome-wide association studies (XWAS) have identified susceptibility variants for various neurodegenerative and neurodevelopmental diseases. The unique characteristics of the chromosome require more complex analytical approaches than standard genome-wide association studies. Over the past 2 decades, refined XWAS methods have better accounted for this biology. Given that many neurological diseases show sex-biased prevalence, XWAS offers a valuable framework for investigating sex-specific genetic contributions. This review summarizes published neurological XWAS ( = 10), highlighting methodological approaches. Despite the challenges of genetic analyses for the X chromosome, XWAS remains a key approach for studying its role in disease mechanisms.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12343220 | PMC |
| http://dx.doi.org/10.3389/fgene.2025.1650259 | DOI Listing |
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