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Introduction: Parastomal hernia (PSH) is a common long-term complication following stoma creation. The incidence of PSH exceeds 50% in long-term follow-up of end colostomy patients, while it remains lower in ileostomies and ileal conduit urinary diversions. PSH prevention strategies are of interest due to the poor outcomes and high recurrence rates associated with PSH repair.
Overview Of Techniques To Prevent Psh: Various technical approaches have been explored to reduce the risk of PSH. However, none have shown consistent benefit toward reducing PSH rate without the use of prophylactic mesh. The keyhole mesh technique was the first to demonstrate a significant reduction in PSH rates in early trials, but larger randomized controlled trials (RCTs) have later questioned its efficacy. The modified keyhole technique, using a funnel-shaped mesh, has shown promising results in recent small studies, with lower PSH incidence and potentially reduced stomal prolapse rate. Other methods such as the Sugarbaker technique and use of biological meshes in PSH prevention have been evaluated as well, with mixed results. While most research focuses on end colostomy, there is limited data on PSH prevention in ileostomies and ileal conduits.
Conclusion: Despite early enthusiasm, the keyhole technique has not proven to be effective in preventing PSH. The modified funnel-shaped mesh appears to be a promising development, though long-term outcomes are lacking. Preventive mesh placement is still supported by international guidelines; however, these recommendations are not widely followed in colorectal surgery departments. Thus, further research is essential to guide future recommendations for PSH prevention.
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http://dx.doi.org/10.3389/jaws.2025.15011 | DOI Listing |
Proc Natl Acad Sci U S A
September 2025
Department of Structural Biology, University of Pittsburgh, Pittsburgh, PA 15213.
Brivaracetam (BRV) and levetiracetam (LEV) are antiseizure medications (ASMs); UCB-J is a PET tracer targeting synaptic vesicle protein 2A (SV2A); UCB7361 is closely related to padsevonil, an experimental anticonvulsant; while UCB1244283 acts as an allosteric modulator for BRV and LEV binding but not for these other ligands. The SV2A-BRV-UCB1244283 structure reveals how UCB1244283 allosterically enhances BRV binding by occupying an allosteric site near the primary binding site, preventing BRV dissociation. This allosteric site, formed by hydrophobic and uncharged residues, is an uncharacterized small-molecule binding site in SV2A.
View Article and Find Full Text PDFWorld J Surg
August 2025
Department of Colorectal Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China.
Background: Parastomal hernia (PSH) is a frequent complication of abdominoperineal resection (APR), yet large-scale studies characterizing its long-term incidence and tools for individualized risk stratification remain lacking. To determine the long-term incidence, independent risk factors, and develop a clinical prediction model for PSH after APR in rectal cancer patients.
Methods: We conducted a retrospective cohort study of 836 patients with rectal adenocarcinoma who underwent APR and permanent end colostomy at a high-volume tertiary center (2014-2018).
World J Surg
August 2025
Departments of General Surgery, Affiliated Hospital of Qingdao University, Qingdao, China.
Background: Parastomal hernia (PSH) is a frequent complication of enterostomy, often resulting from the gradual expansion of the abdominal wall aperture. This retrospective study evaluated a novel surgical technique designed to reduce PSH incidence by stabilizing aperture size over time.
Methods: Patients who underwent permanent colostomies at the Department of Gastroenterology, Qingdao University Affiliated Hospital, between March 2020 and December 2023 were retrospectively reviewed.
Neurology
September 2025
Department of Neurology, Yale School of Medicine, New Haven, CT.
Background And Objectives: Common genetic variation significantly influences the risk of stroke, and previous research has indicated that polygenic susceptibility to hypertension and diabetes negatively affects the clinical trajectory of ischemic stroke survivors. We hypothesize that polygenic susceptibility to hyperlipidemia (PSH) negatively affects cholesterol control in this same population.
Methods: We conducted a genetic association study using data from the Vitamin Intervention Stroke Prevention (VISP) study, a clinical trial that enrolled survivors of ischemic stroke.
J Abdom Wall Surg
July 2025
Gastrointestinal Surgery Department, Oulu University Hospital, Medical Research Center Oulu, Oulu, Finland.
Introduction: Parastomal hernia (PSH) is a common long-term complication following stoma creation. The incidence of PSH exceeds 50% in long-term follow-up of end colostomy patients, while it remains lower in ileostomies and ileal conduit urinary diversions. PSH prevention strategies are of interest due to the poor outcomes and high recurrence rates associated with PSH repair.
View Article and Find Full Text PDF