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Intracerebral hemorrhage (ICH) associated with primary and metastatic brain tumors presents a significant challenge in neuro-oncology due to the substantial risk of complications [...].
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http://dx.doi.org/10.3390/cancers17152502 | DOI Listing |
Pharm Dev Technol
September 2025
School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, wenhua Road 103, Shenyang 110016, PR China.
Nimodipine (NMP), a poorly water-soluble small-molecule agent, demonstrates notable therapeutic limitations in addressing cerebral vasospasm secondary to subarachnoid hemorrhage (SAH). Owing to its inherent physicochemical properties characterized by low oral bioavailability, rapid elimination half-life, and extensive first-pass metabolism, conventional formulations necessitate frequent dosing regimens to sustain therapeutic plasma concentrations. These pharmacological challenges collectively result in suboptimal patient adherence, marked plasma concentration fluctuations, and recurrent vascular irritation.
View Article and Find Full Text PDFNeurocrit Care
September 2025
Department of Neurology and Neurosurgery, Division of Neurocritical Care, Emory University School of Medicine, Atlanta, GA, USA.
Acta Neurochir (Wien)
September 2025
Department of Neurosurgery, Kurume University School of Medicine 67, Asahimachi Kurume City, Fukuoka, 830-0011, Japan.
We report a 64-year-old woman who developed symptomatic vasospasm on postoperative day 7 after clipping of an unruptured right middle cerebral artery (MCA) aneurysm. Imaging revealed right MCA vasospasm, which resolved with oral antiplatelets and intravenous vasodilators. She was discharged without neurological deficits.
View Article and Find Full Text PDFMedicine (Baltimore)
September 2025
Emergency Department, The Second Affiliated Hospital of Shandong First Medical University, Tai'an, China.
Intracerebral hemorrhage (ICH) is a severe and often fatal brain disorder. Despite the recognition of dietary adjustments as a preventive measure, there is a need for well-designed studies to investigate the dietary factors of ICH patients. We employed Mendelian randomization to explore the relationship between 35 dietary factors (exposures) and ICH (outcome).
View Article and Find Full Text PDFMedicine (Baltimore)
September 2025
Department of Radiology, University of Health Sciences Turkey, Istanbul Haseki Training and Research Hospital, Istanbul, Turkey.
In our study, we performed both computed tomographic angiography (CTA) and digital substraction angiography (DSA) collateral artery flow scoring in anterior system acute stroke patients who underwent mechanical thrombectomy (MT) within the first 16 hours. The study aimed to evaluate the consistency of both scoring methods and their relationship with the 90-day clinical outcomes of the patients. From January to December 2022, the files of patients with middle cerebral artery occlusion who underwent MT and were followed up at a stroke center were retrospectively reviewed.
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