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This study examines the associations between linearly scored phenotypic traits and auction sales prices of young event horses in Ireland, aiming to identify key traits influencing market value. Data from 307 horses sold at public auctions (2022-2023) were analysed using regression analysis, binary optimisation, and Principal Component Analysis (PCA). Regression identified Head-neck Connection, Quality of Legs, Walk length of Stride, and Scope as highly significant predictors of sales price ( < 0.001), with Length of Croup, Trot Elasticity, Trot Balance, and Take-off Direction also significant ( < 0.05). Optimised regression reduced the number of relevant traits from 37 to 8, streamlining evaluation. PCA highlighted eight principal traits, including Scope, Elasticity, and Canter Impulsion, explaining 61.19% of variance in the first four components. These results demonstrate that specific conformation, movement, and athleticism traits significantly affect auction outcomes. The findings provide actionable insights for breeders and stakeholders, suggesting that targeted selection for high-impact traits could accelerate genetic progress and improve market returns. Furthermore, these traits could underpin the development of economic or buyer indices to enhance valuation accuracy and transparency, with potential application across equestrian disciplines to align breeding objectives with market demands.
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http://dx.doi.org/10.3390/ani15152227 | DOI Listing |
Neurol Med Chir (Tokyo)
September 2025
Department of Neurosurgery, Graduate School of Biomedical and Health Sciences, Hiroshima University.
Intra-aneurysmal thrombus formation is crucial for the healing of endovascularly treated aneurysms. This study evaluated whether T1-weighted black blood imaging can monitor thrombus formation by examining the relationship between chronological signal intensity changes and aneurysm occlusion status after flow diverter stenting and coil embolization. We retrospectively analyzed 78 patients with 83 aneurysms (flow diverter stenting: 28, coil embolization: 55) who underwent T1-weighted black blood imaging at 1 week, 3 months, and 6 months post-treatment.
View Article and Find Full Text PDFJ Arthroplasty
September 2025
Implant Research Core, School of Biomedical Engineering, Science, and Health Systems, Drexel University, Philadelphia, PA, USA.
Background: In a subset of total hip arthroplasty (THA) patients, investigators associate metal release with biological complications. Comparatively, metal release in the knee is less understood. In this study, we systematically reviewed total knee arthroplasty (TKA) metal release studies.
View Article and Find Full Text PDFMetabolic dysfunction-associated steatotic liver disease (MASLD) is a major global chronic liver condition, with diet-induced inflammation playing a key role in its pathogenesis. This study used 1999-2020 National Health and Nutrition Examination Survey (NHANES) data to assess the association between the Food Inflammation Index (FII) and MASLD risk compared with the Dietary Inflammatory Index (DII). The FII, which is based on 39 food components (via two 24-h dietary recalls), is simpler than the DII (45 components).
View Article and Find Full Text PDFFront Immunol
September 2025
Department of Orthopaedics, Second Affiliated Hospital, Dalian Medical University, Dalian, China.
Objective: To investigate the association between depression and cardiovascular disease (CVD) risk in arthritis patients and evaluate the modifying role of systemic inflammation.
Methods: Using data from the China Health and Retirement Longitudinal Study (CHARLS), we conducted a prospective cohort analysis of 2,571 arthritis patients without baseline CVD. Depression severity was assessed using the 10-item CES-D scale, with scores ≥12 defining depression.
Introduction: Donanemab is an immunoglobulin G1 antibody that targets an N-terminal truncated form of amyloid beta present in mature plaques. Treatment-emergent (TE) anti-drug antibodies (ADAs) were quantified in donanemab-treated participants from two pivotal clinical trials, and effects of TE ADAs on donanemab pharmacokinetics, efficacy, and safety were assessed.
Methods: Data were pooled from the phase 2 TRAILBLAZER-ALZ (NCT03367403) and phase 3 TRAILBLAZER-ALZ 2 trials (NCT04437511).