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Purpose: Data that compare the anterior ethmoidal artery (AEA) with the sphenopalatine artery (SPA) in epistaxis are limited. We intended to compare features of idiopathic epistaxis due to the anterior ethmoidal artery (AEA-epistaxis) with features of idiopathic epistaxis due to the sphenopalatine artery (SPA-epistaxis).
Methods: We conducted a retrospective review of subjects that were hospitalized due to epistaxis between 1st January 2017 and 31st December 2024 at the University Department of Otorhinolaryngology.
Results: In 113 subjects with idiopathic epistaxis, 61 (54%) subjects presented with SPA-epistaxis and 27 (24%) with AEA-epistaxis. The most frequent AEA-epistaxis site was the Stamm's S point (23/27), with the anterior nasal roof following (4/27). Subjects with SPA-epistaxis needed less often (13%) blood transfusion compared to subjects with AEA-epistaxis (30%; p < 0.001). Type of anesthesia differed significantly between subjects with SPA-epistaxis (100% general anesthesia) and subjects with Stamm' S point AEA-epistaxis (30% local anesthesia; p < 0.001). More subjects with initial SPA-epistaxis were re-admitted with severe epistaxis on the same nasal side (4.9%) than subjects with initial AEA-epistaxis (0%; p > 0.2).
Conclusion: In every fourth patient, idiopathic epistaxis might originate from septal branches of AEA, i.e., the Stamm's S point or the anterior nasal roof. Otorhinolaryngologists should not neglect looking for AEA branches during epistaxis. Delay of identification might result in higher blood transfusion rates. In contrast to the SPA, Stamm's S point can be occasionally addressed under local anesthesia, with very low re-admission rates.
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http://dx.doi.org/10.1007/s00405-025-09624-1 | DOI Listing |
Medicine (Baltimore)
September 2025
Department of Pathophysiology, American University of Antigua, Osbourn, Antigua and Barbuda.
Rationale: Idiopathic thrombocytopenic purpura (ITP) is a hematological disorder characterized by a decrease in platelet count due to increased destruction or decreased production. Although the pathophysiology and etiology remain largely unknown, understanding the typical and atypical presentations of ITP is crucial for early diagnosis and effective management. This case report highlights the rationale behind a comprehensive approach for the diagnosis and treatment of ITP, especially in cases with atypical presentations.
View Article and Find Full Text PDFEur Arch Otorhinolaryngol
August 2025
First Department of Otorhinolaryngology, Head and Neck Surgery, Hippocrateion General Hospital, National and Kapodistrian University of Athens, Vas. Sofias 114, 11527, Athens, Greece.
Purpose: Data that compare the anterior ethmoidal artery (AEA) with the sphenopalatine artery (SPA) in epistaxis are limited. We intended to compare features of idiopathic epistaxis due to the anterior ethmoidal artery (AEA-epistaxis) with features of idiopathic epistaxis due to the sphenopalatine artery (SPA-epistaxis).
Methods: We conducted a retrospective review of subjects that were hospitalized due to epistaxis between 1st January 2017 and 31st December 2024 at the University Department of Otorhinolaryngology.
Clin Otolaryngol
August 2025
Department of Otolaryngology-Head and Neck Surgery, Loma Linda University Health, Loma Linda, California, USA.
Objective: To better elucidate the aetiologies, symptomatology, and surgical repair outcomes for nasal septal perforations in the paediatric population.
Study Design: Systematic review and meta-analysis.
Methods: The PubMed, Embase and Web of Science libraries were queried using the terms "nasal septum," "perforation," and "paediatric" and all relevant synonyms.
Lancet Haematol
July 2025
Sobi, Morrisville, NC, USA.
Background: Avatrombopag is an oral thrombopoietin receptor agonist (TPO-RA), taken with food without any specific restrictions, approved for the treatment of adults with chronic immune thrombocytopenia (ITP) who have had an insufficient response to a previous treatment. The aim of this study was to assess the efficacy, safety, tolerability, and pharmacokinetic and pharmacodynamic profile of avatrombopag for children and adolescents with persistent and chronic primary ITP.
Methods: AVA-PED-301 is a global, multicentre, randomised, double-blind, placebo-controlled, parallel-group, phase 3b study.
Front Pharmacol
April 2025
Department of Respiratory and Critical Care Medicine, Affiliated Hospital of Zunyi Medical University, Zunyi, China.
Introduction: To date, only two drugs, pirfenidone and nintedanib, are approved for the treatment of patients with idiopathic pulmonary fibrosis (IPF). In addition, very few studies have reported on the safety profile of either drug in large populations. This study aims to identify and compare adverse drug events (ADEs) associated with pirfenidone and nintedanib in real-world settings by analyzing data from the US Food and Drug Administration Adverse Event Reporting System (FAERS).
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