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Article Abstract
The use of the common marmoset () for neuroscientific inquiry has grown precipitously over the past two decades. Despite windfalls of grant support from funding initiatives in North America, Europe, and Asia to model human brain diseases in the marmoset, marmoset-specific apparatus are of sparse availability from commercial vendors and thus are often developed and reside within individual laboratories. Through our collective research efforts, we have designed and vetted myriad designs for awake or anesthetized magnetic resonance imaging (MRI), positron emission tomography (PET), computed tomography (CT), as well as focused ultrasound (FUS), electrophysiology, optical imaging, surgery, and behavior in marmosets across the age-span. This resource makes these designs openly available, reducing the burden of de novo development across the marmoset field. The computer-aided-design (CAD) files are publicly available through the Marmoset Brain Connectome (MBC) resource (https://www.marmosetbrainconnectome.org/apparatus/) and include dozens of downloadable CAD assemblies, software and online calculators for marmoset neuroscience. In addition, we make available a variety of vetted touchscreen and task-based fMRI code and stimuli. Here, we highlight the online interface and the development and validation of a few yet unpublished resources: software to automatically extract the head morphology of a marmoset from a CT and produce a 3D printable helmet for awake neuroimaging, and the design and validation of 8-channel and 14-channel receive arrays for imaging deep structures during anatomical and functional MRI.
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| http://dx.doi.org/10.1162/imag_a_00483 | DOI Listing |
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An open access resource for marmoset neuroscientific apparatus.
Imaging Neurosci (Camb)
February 2025
Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States.
The use of the common marmoset () for neuroscientific inquiry has grown precipitously over the past two decades. Despite windfalls of grant support from funding initiatives in North America, Europe, and Asia to model human brain diseases in the marmoset, marmoset-specific apparatus are of sparse availability from commercial vendors and thus are often developed and reside within individual laboratories. Through our collective research efforts, we have designed and vetted myriad designs for awake or anesthetized magnetic resonance imaging (MRI), positron emission tomography (PET), computed tomography (CT), as well as focused ultrasound (FUS), electrophysiology, optical imaging, surgery, and behavior in marmosets across the age-span.
View Article and Find Full Text PDFAn Open Access Resource for Marmoset Neuroscientific Apparatus.
bioRxiv
November 2024
Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Article Synopsis
- The common marmoset has become increasingly popular in neuroscience research over the past 20 years, especially for studying human brain diseases, but marmoset-specific research tools are often limited and must be created within labs.
- A team has designed and tested various imaging and measurement techniques for studying marmosets, including MRI, PET, CT, and electrophysiology, and has made these designs publicly accessible to help ease the burden on researchers.
- They provide numerous computer-aided design (CAD) files, software, and resources, including tools for neuroimaging and experimental stimuli, through the Marmoset Brain Connectome website to support further advancements in marmoset neuroscience.
An ethologically motivated neurobiology of primate visually-guided reach-to-grasp behavior.
Curr Opin Neurobiol
June 2024
Cortical Systems and Behavior Laboratory, Neurosciences Graduate Program, University of California at San Diego, USA. Electronic address:
The precision of primate visually guided reaching likely evolved to meet the many challenges faced by living in arboreal environments, yet much of what we know about the underlying primate brain organization derives from a set of highly constrained experimental paradigms. Here we review the role of vision to guide natural reach-to-grasp movements in marmoset monkey prey capture to illustrate the breadth and diversity of these behaviors in ethological contexts, the fast predictive nature of these movements [1,2], and the advantages of this particular primate model to investigate the underlying neural mechanisms in more naturalistic contexts [3]. In addition to their amenability to freely-moving neural recording methods for investigating the neural basis of dynamic ethological behaviors [4,5], marmosets have a smooth neocortical surface that facilitates imaging and array recordings [6,7] in all areas in the primate fronto-parietal network [8,9].
View Article and Find Full Text PDFDomain-specific cognitive impairment reflects prefrontal dysfunction in aged common marmosets.
bioRxiv
May 2023
Systems Neurobiology Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037.
Unlabelled: Age-related cognitive impairment is not expressed uniformly across cognitive domains. Cognitive functions that rely on brain areas that undergo substantial neuroanatomical changes with age often show age-related impairment, while those that rely on brain areas with minimal age-related change typically do not. The common marmoset has grown in popularity as a model for neuroscience research, but robust cognitive phenotyping, particularly as a function of age and across multiple cognitive domains, is lacking.
View Article and Find Full Text PDFAn open access resource for functional brain connectivity from fully awake marmosets.
Neuroimage
May 2022
Department of Neurobiology, University of Pittsburgh, Pittsburgh, PA 15261, United States.
The common marmoset (Callithrix jacchus) is quickly gaining traction as a premier neuroscientific model. However, considerable progress is still needed in understanding the functional and structural organization of the marmoset brain to rival that documented in longstanding preclinical model species, like mice, rats, and Old World primates. To accelerate such progress, we present the Marmoset Functional Brain Connectivity Resource (marmosetbrainconnectome.
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