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Aims & Objectives: The compression of the spinal cord can result in degenerative cervical myelopathy (DCM), a condition characterized by progressive neurological dysfunction.This study examines clinical outcomes after anterior decompression and predictors of secondary posterior decompression after initial anterior surgery.
Materials & Methods: We conducted a retrospective review of 94 consecutive patients who underwent anterior-only cervical decompression in DCM. Preoperative variables (demographics, neurological and clinical status, spine anatomy) were entered into a multivariate logistic regression to determine associations with secondary posterior decompression. Neurologic function was assessed by the JOA score.
Results: Nine of 94 patients (9.6 %) underwent secondary posterior decompression for persistent myelopathic symptoms, of which all presented with a concentric spinal canal stenosis. In multivariate analysis, higher ASA score (p = 0.042), concentric stenosis (p = 0.008) and osteoporosis (p = 0.044) were independently associated with increased revision risk. At six weeks, the anterior-only cohort achieved a mean JOA score of 15.44, compared to 12.60 in those undergoing revision (measured pre-revision).
Conclusion: Concentric stenosis morphology, compromised bone quality, and elevated ASA status independently predict failure of anterior-only decompression. In patients exhibiting this high-risk profile, a primary combined anterior-posterior approach should be strongly considered to ensure circumferential decompression and optimize early neurologic recovery.
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http://dx.doi.org/10.1016/j.jor.2025.07.019 | DOI Listing |
Open Heart
August 2025
Cardiovascular Institute, Thorax Center, Department of Cardiology, Erasmus MC, Rotterdam, The Netherlands
Background: Previous research on congenital aortic stenosis (AS) mainly focused on children, while data on long-term outcomes in adults is scarce. Therefore, this study aims to evaluate outcomes in adult patients with congenital AS and identify prognostic markers for aortic valve replacement (AVR).
Methods: In this multicentre study, patients aged 18-55 years with congenital AS (peak velocity ≥2.
J Orthop
October 2025
Spine Center, St. Josefs-Hospital, Wiesbaden, Germany.
Aims & Objectives: The compression of the spinal cord can result in degenerative cervical myelopathy (DCM), a condition characterized by progressive neurological dysfunction.This study examines clinical outcomes after anterior decompression and predictors of secondary posterior decompression after initial anterior surgery.
Materials & Methods: We conducted a retrospective review of 94 consecutive patients who underwent anterior-only cervical decompression in DCM.
Eur Heart J Case Rep
July 2025
Division of Cardiovascular Medicine, University of Virginia Health System, Charlottesville, VA 22902, USA.
Background: Hypertrophic cardiomyopathy (HCM) is a relatively common genetic disorder often associated with left ventricular outflow tract (LVOT) obstruction. However, the presence of certain structural abnormalities such as supravalvular aortic stenosis (SVAS) can contribute to elevated LVOT gradients and thereby mimic obstructive HCM. This case highlights the importance of multimodality imaging in accurately determining the aetiology of LVOT obstruction, which is critical to guiding appropriate management.
View Article and Find Full Text PDFSystemic lupus erythematosus (SLE) is an enigmatic autoimmune disease with a varied presentation that carries with it an increased risk for many potentially life-threatening problems. When compared with the general population, the relative risk of ischemic stroke in SLE is more than doubled. Our case report highlights a rare complication of SLE, vasculitis as the cause of stroke.
View Article and Find Full Text PDFBasic Res Cardiol
July 2025
Institute for Cardiovascular Prevention (IPEK), Ludwig-Maximilians-Universität (LMU) Munich, Munich, Germany.
In patients, severity of pressure-induced heart failure (HF) due to aortic stenosis and metabolic disorder correlates with thickness and mass of epicardial adipose tissue (EAT). We examined the role of the less studied pericardial adipose tissue (PAT) during manifestation and progression of pressure-induced HF in mice. Progressive remodeling was assessed in C57BL/6 J males, aged 9 weeks, following sham surgery or transverse aortic constriction (TAC) for 1 week (early pressure-overload), 8 (chronic pressure-overload), or 12 weeks (HF with reduced ejection fraction, HFrEF) with or without concomitant PAT excision.
View Article and Find Full Text PDF