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In a scanning imaging system through a scattering medium, the quality of the imaging result is related to the energy distribution of the focusing point. In actual imaging, the energy of the focusing point cannot be perfectly concentrated. The scattering noise is always surrounded by the focusing point, which reduces the signal-to-noise ratio and results in poor image quality. To improve the quality of imaging, further processing of the imaging results is required, while most conventional image processing methods can only achieve one of the goals such as noise reduction, image smoothing, edge sharpening, or maintaining image integrity. In this paper, a scanning imaging system through the scattering medium based on an adaptive guided filter assisted by the wavelet transform modulus maximum (WTMM) and non-local mean (NLM) is proposed for the first time, to the best of our knowledge, which can make the imaging results simultaneously have the advantages of low noise, high contrast, and clear details. To verify the validity of the proposed method, a scanning imaging system through the scattering medium was setup. Transmissive imaging was performed at different positions from the focal plane. The experimental results show that the background noise is significantly restrained, single-pixel response and edge continuity are good, and details are clear with the proposed method. Compared with the traditional methods and the deep learning methods, the proposed method can improve the PSNR and SSIM by up to 10.68 dB, 0.75 and 5.34 dB, 0.72, respectively. Finally, the performance of the proposed method in high-noise environments, its application in the field of real-time imaging, and future improvements are discussed. The method proposed in this paper can effectively improve the quality of scanning imaging results through the scattering medium, which is expected to promote the application of this technology in endoscopic imaging and other fields.
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http://dx.doi.org/10.1364/AO.550068 | DOI Listing |
JAMA
September 2025
Division of Surgery and Interventional Science, UCL, London, United Kingdom.
Importance: Multiparametric magnetic resonance imaging (MRI), with or without prostate biopsy, has become the standard of care for diagnosing clinically significant prostate cancer. Resource capacity limits widespread adoption. Biparametric MRI, which omits the gadolinium contrast sequence, is a shorter and cheaper alternative offering time-saving capacity gains for health systems globally.
View Article and Find Full Text PDFJAMA Cardiol
September 2025
Seymour, Paul and Gloria Milstein Division of Cardiology, Department of Medicine, Columbia University Irving Medical Center and New York-Presbyterian Hospital, New York, New York.
Importance: Transthyretin cardiac amyloidosis (ATTR-CA) is an underdiagnosed but treatable cause of heart failure (HF) in older individuals that occurs in the context of normal wild-type (ATTRwt-CA) or an abnormal inherited (ATTRv-CA) TTR gene variant. While the most common inherited TTR variant, V142I, occurs in 3% to 4% of self-identified Black Americans and is associated with excess morbidity and mortality, the prevalence of ATTR-CA in this at-risk population is unknown.
Objective: To define the prevalence of ATTR-CA and proportions attributable to ATTRwt-CA or ATTRv-CA among older Black and Caribbean Hispanic individuals with HF.
J Magn Reson Imaging
September 2025
Department of Diagnostic Imaging and Nuclear Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Background: Carotid artery stenosis is a major cause of stroke. Non-contrast MR angiography (MRA) using time-spatial labeling inversion pulse (Time-SLIP) may offer potential advantages over 3D time-of-flight (TOF)-MRA for simultaneous visualization of carotid, vertebral, and subclavian arteries, but remains uninvestigated.
Purpose: To determine optimal black blood inversion time (TI) for visualizing the carotid and subclavian arteries using three-dimensional (3D) fast field echo (FFE) Time-SLIP MRA, and to compare its image quality with 3D TOF-MRA.
Invest Ophthalmol Vis Sci
September 2025
Center for Visual Science, University of Rochester, Rochester, NY, United States.
Purpose: Adaptive optics scanning light ophthalmoscopy (AOSLO) paired with intravitreal injection of a viral vector coding for the calcium indicator GCaMP has enabled visualization of neuronal activity in retinal ganglion cells (RGCs) at single cell resolution in the living eye. However, the inner limiting membrane (ILM) restricts viral transduction to the fovea in humans and non-human primates, hindering both therapeutic intervention and physiological study of the retina. To address this issue, we explored peeling the ILM before intravitreal injection to expand calcium imaging beyond the fovea in the living primate eye.
View Article and Find Full Text PDFMicrosc Res Tech
September 2025
Department of River Ecology, Helmholtz Centre for Environmental Research-UFZ, Magdeburg, Germany.
This review is intended as a guideline for beginners in confocal laser scanning microscopy. It combines basic theoretical concepts, such as fluorescence principles, resolution limits, and imaging parameters with practical guidance on sample preparation, staining strategies, and data acquisition using confocal microscopy. The aim is to combine technical and methodological aspects in order to provide a comprehensive and accessible introduction.
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