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Infective endocarditis is a common and morbid condition involving prolonged hospital stays, significant disability, and a high mortality rate. The current crises of injection drug use and opioid use disorder have contributed to high rates of infective endocarditis in the United States. Endocarditis in patients who inject drugs involves additional management complexity for multiple reasons. Several infective endocarditis management guidelines exist, including from the American Heart Association and the European Society of Cardiology. In light of the unique challenges of caring for this particular population, in 2022 the American Heart Association published a scientific statement specifically focusing on infective endocarditis in people who inject drugs. In these rounds, 2 experts in their respective fields, an infectious diseases specialist and a cardiac surgeon, discuss medical management, interventional approaches, and the value of multidisciplinary care for tricuspid valve endocarditis in a person who uses injection drugs, both in general and in relation to Mr. Y, a 30-year-old man with a history of substance use disorder, methicillin-sensitive bacteremia, and right-sided endocarditis.
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http://dx.doi.org/10.7326/ANNALS-25-02049 | DOI Listing |
JTCVS Open
August 2025
Division of Cardiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
Objective: To compare the clinical outcomes of double-valve replacement (DVR) using bovine pericardial and porcine bioprostheses, using a nationwide administrative claims database.
Methods: Adult patients (age ≥40 years) who underwent bioprosthetic DVR between 2003 and 2018 were identified from the Korean National Health Insurance Service database. The outcomes of interest were all-cause mortality, cardiac mortality, and valve-related events, including the incidences of reoperation, endocarditis, systemic thromboembolism, and major bleeding.
JTCVS Open
August 2025
Division of Cardiac Surgery, IRCCS Azienda Ospedaliera-Universitaria di Bologna, Bologna, Italy.
Objective: To compare early and long-term clinical outcomes of bioprosthetic versus mechanical (On-X) mitral valve replacement (MVR) in patients aged 65 years and older.
Methods: This single-center retrospective study included consecutive patients equal to or older than 65 years underwent isolated MVR from 2005 to 2023. A propensity score-matched analysis was performed to compare early- and long-term clinical outcomes between patients with bioprostheses and mechanical On-X valve.
JTCVS Open
August 2025
Department of Cardiovascular Surgery, Mayo Clinic, Rochester, Minn.
Objective: To evaluate the early postoperative morbidity, mortality, and prosthetic conduit function of patients who underwent aortic root replacement using a prefabricated bioprosthetic aortic valved conduit.
Methods: Single-center retrospective review of 124 consecutive adult patients who underwent aortic root replacement with a certified prefabricated bioprosthetic aortic valved conduit from 2021 to December 2023.
Results: Indications for operation were aortic aneurysms (n = 92), endocarditis (n = 12), deterioration of prior valve prosthesis (n = 13), and aortic dissection (n = 6).
Cureus
August 2025
Internal Medicine, Ronald Reagan University of California Los Angeles Medical Center, Los Angeles, USA.
Although generally considered harmless commensals or beneficial probiotics, species can act as opportunistic pathogens under certain clinical conditions. We describe a case of high-grade bacteremia in a 59-year-old man with a history of aortic root dilation status post Bentall procedure and bioprosthetic aortic valve replacement. The suspected source was recent dental instrumentation.
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August 2025
Acute Internal Medicine, University Hospitals of North Midland, Royal Stoke University Hospital, Stoke-on-Trent, GBR.
Infective endocarditis is a potentially fatal condition that can present with non-specific symptoms and rare hematologic manifestations, posing significant diagnostic challenges. We report a compelling case of a 67-year-old male with a history of type 2 diabetes, hypertension, and hyperlipidemia who sought medical attention for a five-month history of progressive iron deficiency anemia, accompanied by weight loss, fatigue, and vague constitutional symptoms. Initial extensive workup, including computed tomography of the thorax, abdomen, and pelvis, gastroscopy, colonoscopy, and transthoracic echocardiography, failed to identify an underlying cause.
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