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Article Abstract
PDZ (PSD-95/Discs-large/ZO-1) domains canonically interact with the C termini of partner proteins; however, they also bind internal motifs. In this issue of Structure, Kumar et al. uncover a novel function of PDZ domains, revealing a dynamic binding mode that alternates between a C-terminal and an internal motif within the same ligand.
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| http://dx.doi.org/10.1016/j.str.2025.07.004 | DOI Listing |
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