Real-World Data of the First UK Series of MINIject Supraciliary Glaucoma Implant with 6 Months Follow-Up.

Introduction: This study evaluates the efficacy and safety of the MINIject (iStar Medical, Wavre, Belgium) supraciliary implant for the treatment of glaucoma.

Methods: Patients with medically uncontrolled primary open angle glaucoma, primary angle closure glaucoma and normal tension glaucoma were included. This first in the UK, retrospective, single-centre, interventional study evaluated the implantation of the MINIject in 50 eyes, including 11 stand-alone cases and 39 cases combined with phacoemulsification. The primary outcome was mean reduction of intraocular pressure (IOP) at 6 months. We also report the proportion of eyes that achieved a final IOP ≤ 21 mmHg and > 5 mmHg with an IOP reduction of ≥ 20% with/without medication use.

Results: Mean (± standard deviation) baseline IOP was 18.4 ± 4.7 mmHg on 2.1 ± 1.1 medications. There was a significant decrease in IOP at 6 months (-6.3; 95% confidence interval [CI] -2.9 to -9.7 mmHg, P < 0.001). There was no significant association between diagnosis, mode of delivery (stand-alone/combined with phacoemulsification) and the degree of IOP lowering. There was a significant decrease in IOP-lowering medications at 6 months (-2.1; 95% CI -1.6 to -2.6 mmHg, P < 0.001). A total of 88.9% of eyes achieved a final IOP ≤ 21 mmHg and > 5 mmHg, whilst 57.8% of eyes achieved this combined with 20% reduction in IOP. Adverse events occurred in 15.6% (n = 7) of eyes. No sight-threatening events occurred.

Conclusions: This study shows promising IOP-lowering results and medication reduction over 6 months with few adverse events.