One-step synthesis of 2-arylindoles from indolines Pd-catalyzed oxidative dehydrogenation and C2-selective arylation. | LitMetric

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One-step synthesis of 2-arylindoles from indolines Pd-catalyzed oxidative dehydrogenation and C2-selective arylation. | LitMetric

One-step synthesis of 2-arylindoles from indolines Pd-catalyzed oxidative dehydrogenation and C2-selective arylation.

Yo-Sep Yang , Jiyeon Yoo , Juhyeon Jeon , Jun Hwi Bak , Jeong-Won Shin , Hyuck-Jae Won , Hee Sung Hwang , Ju Hee Kim , Jaehoon Sim , Nam-Jung Kim

RSC Adv

Department of Pharmacy, College of Pharmacy, Kyung Hee University Seoul 02447 Republic of Korea

Published: August 2025

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We report an efficient synthetic approach to 2-arylindoles from indolines a one-step process involving Pd-catalyzed oxidative dehydrogenation and a sequential C2-regioselective Heck-type reaction. The mild reaction conditions, which utilize O as the sole oxidant, show a broad substrate scope and good functional group compatibility.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12329653	PMC
http://dx.doi.org/10.1039/d5ra04628a	DOI Listing

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