Bioactive Nanomaterials: Comprehensive Monitoring and Regulation of Acute Pancreatitis Induced Acute Lung Injury.

Mounting evidence suggests acute lung injury (ALI) or acute respiratory distress syndrome (ARDS) is a complication of acute pancreatitis (AP), a disorder associated with several health challenges, a common cause of multiple organ damage, and a contributing factor to mortality. The exact mechanism behind the disorder has not been fully understood over the years, although what is mostly known is that the intensity of the AP in turn plays a significant role in the state of the ALI/ARDS. The eradicative role via conventional/pharmacological intervention has caused only little impact over the years. However, the nanotechnological advancement over the years may set the stage for ameliorating the condition. This review seeks to expound on the possible potential embedded with bioactive nanomaterials tackling the limitations faced by conventional drugs by highlighting AP and its associated ALI/ARDS, the nanotechnological role in the face of the loopholes of the conventional intervention, and the use of bioactive nanomaterials ranging from anti-inflammatory to anti-oxidant for the modulation ALI/ARDS. In addition, other modulating effects of bioactive-nanoparticles, the application of nanocomposite/hybrid nanoparticles and the conclusion and future perspective encompassing the cytotoxic effect and other concerns. In all, understanding the mechanisms and the bioactive nanomaterials potential roles may create a platform that can be of potential clinical value.