Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Background: Heart regeneration requires renewal of lost cardiomyocytes. However, the mammalian heart loses its proliferative capacity soon after birth, and the molecular signaling underlying the loss of cardiac proliferation postnatally is not fully understood.
Purpose: This study aimed to investigate the role of Catenin alpha 3 (), coding for alpha T catenin (αT-catenin) protein in regulating cardiomyocyte proliferation and heart regeneration during the neonatal period.
Methods: Here we report that ablation of and highly expressed in hearts, accelerated heart regeneration following heart apex resection in neonatal mice.
Results: Our results show that deficiency enhances cardiomyocyte proliferation in hearts from postnatal day 7 (P7) mice by upregulating Yes-associated protein (Yap) expression.
Conclusion: Our study demonstrates that deficiency is sufficient to promote heart regeneration and cardiomyocyte proliferation in neonatal mice and indicates that functional interference of α-catenins might help to stimulate myocardial regeneration after injury.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.31083/FBL39676 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
The emergence of drug-resistant bacteria due to excessive antibiotic use has drawn increasing attention to inorganic nanoparticles for their broad-spectrum antibacterial properties. Here, a "green" strategy for the simultaneous in situ synthesis of silver nanoparticles (AgNPs) during the photocrosslinking process of casein hydrogels is described. The in situ photoactivated biomineralization of AgNPs provides noticeable stability and antibacterial activity, with high photothermal effect during a sequential near-infrared laser activation.
View Article and Find Full Text PDFINVESTIGATIONAL AGENTS FOR ISCHAEMIC CARDIOMYOPATHY TREATMENT: PRECLINICAL AND EARLY PHASE INSIGHTS.
Expert Opin Investig Drugs
September 2025
Heart Failure Clinic, Division of Cardiology, Alessandro Manzoni Hospital, ASST Lecco, Lecco, Italy.
Introduction: Ischemic heart disease (IHD) constitutes the most prevalent form of cardiac disease in the general population. Although current therapeutic interventions have significantly improved both quality of life and survival rates, no available treatment can reverse the loss of cardiomyocytes resulting from ischemic injury. Existing therapies are limited to attenuating myocardial damage, reducing its extent, and mitigating its clinical consequences.
View Article and Find Full Text PDFInnovations in cardiac regenerative medicine: The role of tissue engineering.
Int J Artif Organs
September 2025
Department of Clinical Engineering, Faculty of Medical Science and Technology, Gunma Paz University, Takasaki-shi, Gunma, Japan.
Cardiovascular disease (CVD) is a leading cause of death worldwide. CVD includes conditions such as myocardial infarction (MI), arrhythmias, valvular heart disease, and cardiomyopathy. The limitations of heart treatment are related to the inability of damaged cells to regenerate, which leads to an increasing demand for new therapies.
View Article and Find Full Text PDFTranscriptional regulation in heart development, disease and regeneration: reassessing the fetal gene hypothesis.
Nat Rev Cardiol
September 2025
Murdoch Children's Research Institute, The Royal Children's Hospital, Melbourne, Victoria, Australia.
A central paradigm in cardiac biology is the reactivation of the fetal gene programme in the adult heart in response to stress. This so-called 'fetal gene hypothesis' was first proposed almost 40 years ago following the observation that certain fetal contractile protein isoforms were re-expressed in hypertrophied ventricles in the rodent heart in response to haemodynamic overload. Consequently, this concept was broadly adopted, and activation of the fetal gene programme became synonymous in the literature with the cardiac stress response.
View Article and Find Full Text PDFRecent Advances in Cardiac Tissue Engineering: Innovations and Future Directions.
Biotechnol J
September 2025
College of Medicine, Al-Ayen Iraqi University, An Nasiriyah, Iraq.
Cardiac tissue engineering (CTE) is a rapidly evolving field that combines cells, scaffolds, and biofabrication methods to repair damaged heart tissue. New technologies have made it possible to utilize AI in designing cardiac patches and 4D bioprinting to create biomaterials that respond to time. These procedures are a big step forward from traditional ones since they offer more accuracy, flexibility, and the possibility of therapies that are tailored to each patient.
View Article and Find Full Text PDF