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http://dx.doi.org/10.1111/aos.17571 | DOI Listing |
Front Immunol
September 2025
Department of Clinical Oncology, University of Hong Kong-Shenzhen Hospital, Shenzhen, China.
Background: Neoantigen-based vaccines show promising therapeutic potential in solid tumors such as melanoma, GBM, NSCLC, and CRC. However, clinical responses remain suboptimal in stage IV patients, due to ineffective T-cell function and high tumor burdens. To overcome these limitations, our study investigates a combination strategy using neoantigen peptide vaccines and precision critical lesion radiotherapy (CLERT), which delivers immunomodulatory doses to key tumor regions synergistically enhance immune activation and inhibit progression in multifocal stage IV patients.
View Article and Find Full Text PDFToxicon
September 2025
Research and Innovation Hub, Innovation Aesthetics, London, UK.
Botulinum Neurotoxin Type A (BoNT-A) remains the cornerstone of glabellar frown line treatment, yet conventional low-dose, high-volume protocols often result in limited durability and imprecise diffusion. This study presents multiscale, in silico framework specifically designed to evaluate high-dose (60-80 Units), low-volume (≤0.045 mL/site) BoNT-A glabellar injection strategies across anatomically realistic conditions.
View Article and Find Full Text PDFWorld J Gastroenterol
August 2025
Department of General Surgery, Jiangbei Campus of The First Affiliated Hospital of Army Medical University, Chongqing 400020, China.
Background: Xuanshen decoction (XSD) is a traditional Chinese medicine formulation that is often applied in treating slow transit constipation (STC). However, its specific therapeutic mechanism remains to be characterized.
Aim: To investigate the mechanism of XSD for STC, we combined network pharmacology prediction, molecular docking analysis, and studies.
ACS Omega
August 2025
Universidade de São Paulo, Instituto de Pesquisas Energéticas e Nucleares, IPEN-CNEN/SP, Av. Prof. Lineu Prestes, 2242-Cidade Universitária, São Paulo, SP BR 05508-900, Brazil.
Polylactic acid (PLA), a widely used biopolymer, faces limitations in melt strength and miscibility with poly-(butylene adipate--terephthalate) (PBAT), requiring compatibilization strategies. This study uniquely investigates the combined effects of high dose of gamma irradiation (80-150 kGy) and low-aspect-ratio cellulose nanoparticles (CNPs) on PLA/PBAT blends, aiming to enhance compatibility and mechanical performance. Gamma irradiation induced chain scission and radical formation, improving blend compatibility but reducing mechanical properties at high doses due to excessive chain scission.
View Article and Find Full Text PDFJ Vitreoretin Dis
August 2025
Retina Consultants P.C., Hartford, CT, USA.
To describe 3 cases of intraocular inflammation (IOI) in patients who received faricimab and high-dose aflibercept in consecutive order. Retrospective case review. Three patients, 2 with neovascular age-related macular degeneration (nAMD) and 1 with central retinal vein occlusion (CRVO), transitioned from 2 mg aflibercept to either faricimab (in cases 1 and 2) or high-dose aflibercept (in case 3) due to persistent disease activity.
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