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Background: Despite the high level of economic development in the Group of Seven (G7) countries, injury deaths remain a public health concern in these countries. This paper examines the contribution of injury deaths to changes in life expectancy (LE) and life disparity (LD) in the G7 countries.
Methods: We used annual data from the WHO mortality database to compute LE and LD during 2001-03 and 2017-19. The contributions of injury deaths to LE and LD changes for each sex were decomposed by age and cause using a continuous-change model.
Results: Across the G7 countries combined, LE (LD) increased by 2.12 (0.25) and 2.73 (0.16) years for females and males, respectively. While most injury-related deaths contributed to increases in LE and decreases in LD, these gains were offset by negative contributions of unintentional poisoning, resulting in an overall negligible net contributions of injury deaths to changes in LE/LD across the G7 countries combined. The country-specific patterns revealed notable variations. Positive contributions of injury-related causes to changes in LE were more prominent in France (+ 0.38/+0.64 years for females/males), while negative contributions were most evident in the USA (-0.23/-0.42 years for females/males). Transport accidents emerged as the leading contributors to improvements in both LE and LD among both sexes in all countries, with more pronounced effects in males. In contrast, unintentional poisoning had a substantial negative impact, particularly among younger populations in the USA, UK, and Canada.
Conclusion: Injury deaths made negligible contributions to overall changes in LE and LD across the G7 countries combined during the study period. However, there were important variations by sex, age, cause and country. Specifically, unfavourable contributions of injury deaths were mainly observed in the USA, UK, and Canada. These findings highlight the need for targeted, country-specific injury prevention strategies to mitigate premature and unequal mortality.
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http://dx.doi.org/10.1186/s12963-025-00409-6 | DOI Listing |
JCI Insight
September 2025
Division of Nephrology, Boston University Chobanian & Avedisian School of Medicine, Boston, United States of America.
Background: Active vitamin D metabolites, including 25-hydroxyvitamin D (25D) and 1,25-dihydroxyvitamin D (1,25D), have potent immunomodulatory effects that attenuate acute kidney injury (AKI) in animal models.
Methods: We conducted a phase 2, randomized, double-blind, multiple-dose, 3-arm clinical trial comparing oral calcifediol (25D), calcitriol (1,25D), and placebo among 150 critically ill adult patients at high-risk of moderate-to-severe AKI. The primary endpoint was a hierarchical composite of death, kidney replacement therapy (KRT), and kidney injury (baseline-adjusted mean change in serum creatinine), each assessed within 7 days following enrollment using a rank-based procedure.
Apoptosis
September 2025
Department of Physiology, School of Basic Medical Sciences, Southwest Medical University, Luzhou, 646000, Sichuang, China.
Cardiovascular diseases (CVDs) are a leading cause of death globally, responsible for 32% of all fatalities. They significantly reduce quality of life and life expectancy, while imposing a substantial economic burden on healthcare systems in different countries. High mobility group box 1 (HMGB1), a location-dependent multifunctional protein, plays a significant role in various cell death pathways associated with CVDs.
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September 2025
The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, 182 Chunhui Road, Longmatan District, Luzhou, 646000, China.
Diabetic cardiomyopathy (DCM) is a severe cardiovascular complication of diabetes mellitus, characterized by pathological changes such as cardiomyocyte hypertrophy, necrosis, and myocardial fibrosis, which can ultimately lead to heart failure. However, its underlying mechanisms remain incompletely understood, limiting the development of effective therapeutic approaches. In recent years, the critical roles of oxidative stress and ferroptosis in the pathogenesis of DCM have attracted increasing attention.
View Article and Find Full Text PDFKhirurgiia (Mosk)
September 2025
Sevastopol City Hospital No. 5 - Center for Maternal and Child Health Protection, Sevastopol, Russia.
Objective: To analyze clinical data and predictors of mortality neonatal spontaneous gastric perforation (SGP).
Material And Methods: A two-center retrospective cohort study included neonates diagnosed with SGP between 1999 and 2023. This cohort was divided into survivors and dead neonates to identify prognostic factors of mortality.
J Addict Nurs
September 2025
Cecilie W. Toudahl, MSc, The College of Nursing, University of South Carolina, Columbia, South Carolina.a.
Substance misuse among college students continues to rise, with polysubstance use becoming increasingly common. Alcohol remains the most prevalent substance, with heavy episodic and high-quantity drinking linked to serious consequences, including injuries, assaults, and deaths. Concurrent use of alcohol and cannabis, as well as other illicit drugs, further compounds risks to health, safety, and academic functioning.
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