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Language, both spoken and written, plays a critical role in shaping clinical communication, documentation, research integrity, and patient trust. In obstetric care, terminology must align with biological reality, uphold clinical accuracy, respect patient identity, and increasingly, comply with federal policy. As of January 2025, Executive Order 14,168 reframes gender-inclusive language as a threat to women's dignity, safety, and well-being, asserting that "efforts to eradicate the biological reality of sex fundamentally attack women" and it mandates sex-based language, reversing prior encouragement of gender-inclusive terminology. This shift has created ethical, operational, and legal tensions for clinicians, who must reconcile conflicting expectations from federal mandates, professional guidelines, and patient needs. Several institutions have already experienced funding losses due to noncompliance with evolving mandates, underscoring the stakes of aligning clinical language with policy. This manuscript examines the impact of these developments on obstetric language, drawing on legal frameworks, ethical principles, and professional standards. A PubMed analysis through 2024 reveals the continued predominance of "pregnant woman" (60%), increasing use of "pregnant patient" (20%), and a growing presence of inclusive terms (20%). While sex-based terminology facilitates regulatory compliance and clinical clarity, inclusive language may improve trust among gender-diverse populations. We propose a balanced context-sensitive framework, called Balanced Pregnancy Language, which aligns documentation and billing with federally mandated sex-based terms while allowing patient-preferred, inclusive language in clinical interactions and nonstructured documentation. The Balanced Pregnancy Language model preserves scientific clarity, ensures compliance, and supports ethical commitments to respect patient autonomy. Given recent federal shifts affecting documentation standards and data collection practices, the Balanced Pregnancy Language model offers a balanced and ethically grounded solution. It enables clinicians to meet sex-specific regulatory requirements while respectfully affirming patient identity, thereby preserving both institutional integrity and the ethical delivery of care.
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http://dx.doi.org/10.1016/j.ajog.2025.07.049 | DOI Listing |
Clin Anat
September 2025
Department of Pathology and Laboratory Medicine, All India Institute of Medical Sciences, Bibinagar, Telangana, India.
Hyrtl's anastomosis, a transverse inter-arterial connection between the two umbilical arteries near their placental insertion, plays a vital role in maintaining hemodynamic stability in fetal circulation. Despite being a consistent finding in most term placentas, its functional role and clinical significance are underappreciated in perinatal medicine. This review explores the anatomy, physiological function, diagnostic assessment, and clinical implications of Hyrtl's anastomosis, with emphasis on its protective role in ensuring balanced placental perfusion and mitigating hemodynamic stress in compromised pregnancies.
View Article and Find Full Text PDFMol Genet Genomic Med
September 2025
Laboratory Medicine and Genetics, Trillium Health Partners, Mississauga, Ontario, Canada.
Background: Human chimerism is rare, and most prevalent with discordant chromosomal sex. We report a male 46,XY/46,XY chimera, born through a spontaneously conceived pregnancy to a healthy 32-year-old G1P0 Indian, African, and Scottish female and her 34-year-old healthy Chinese partner. The prenatal presentation and postnatal outcomes are described.
View Article and Find Full Text PDFHum Reprod
September 2025
Boston IVF-IVIRMA Global Research Alliance, Waltham, MA, USA.
Study Question: Does a high proportion of immature oocytes impact embryo development and live birth rates in IVF-ICSI cycles?
Summary Answer: While a high proportion of immature oocytes is associated with lower blastocyst formation and reduced preimplantation genetic testing for aneuploidy (PGT-A) utilization, live birth rates remain comparable when key confounders-such as age, BMI, gonadotropin dosage, and metaphase-II (MII) count-are balanced, but cycles with a very low MII proportion resulted in fewer embryo transfers, which is quantitatively limiting, even if embryo quality appears unaffected.
What Is Known Already: Previous studies have linked a lower proportion of mature oocytes (MII) to decreased fertilization rates, abnormal embryo development, and lower pregnancy and live birth rates. However, it remains unclear whether these outcomes are due to quantitative limitations (fewer mature oocytes available) or qualitative deficiencies (intrinsic oocyte quality issues).
J Med Virol
September 2025
Laboratory of Dermatology and Immunodeficiencies, Department of Dermatology, University of São Paulo Medical School, São Paulo, Brazil.
Mother-to-child transmission (MTCT) is the primary route of human T-lymphotropic virus type 1 (HTLV-1) infection. Although formula feeding reduces breastfeeding-associated transmission, MTCT still occurs, implicating pregnancy or delivery as key transmission windows. In this study, placental tissues from nine HTLV-1-positive mothers were analyzed using DNA/RNAscope, revealing low HTLV-1 DNA and RNA levels and a low RNA/DNA ratio, consistent with latent infection in the placenta and potentially explaining the low MTCT rate.
View Article and Find Full Text PDFBMC Endocr Disord
September 2025
Maternal and Childhood Obesity Research Center, Urmia University of Medical Sciences, Urmia, Iran.
Background: Gestational diabetes mellitus (GDM) is a common pregnancy complication closely associated with increased oxidative stress. The Oxidative Balance Score (OBS) integrates dietary and lifestyle factors influencing oxidative stress, yet its relationship with GDM remains unclear.
Methods: In this case-control study, 150 pregnant women with GDM and 170 healthy controls were recruited from primary healthcare centers in Urmia, Iran.