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Context: Obesity is a recognized risk factor for adverse outcomes in cervical spine surgery. While cervical disc arthroplasty (CDA) has emerged as an alternative to anterior cervical discectomy and fusion (ACDF), comparative outcomes among obese patients remain underexplored.
Aims: The aim of this study is to compare nonroutine discharge rates and other postoperative outcomes between obese patients undergoing single-level ACDF and CDA.
Settings And Design: Retrospective cohort study using a national database.
Subjects And Methods: The National Inpatient Sample was queried to identify obese patients who underwent single-level ACDF or CDA between 2016 and 2020. Inclusion and exclusion criteria were applied. Propensity score matching (1:3) was performed based on age, sex, race, Elixhauser Comorbidity Index, and primary diagnosis to create comparable cohorts. Outcomes included nonroutine discharge, length of stay (LOS), total cost, and postoperative complications.
Statistical Analysis Used: Chi-square tests and Student's t-tests were used for categorical and continuous outcomes, respectively, with significance set at < 0.05.
Results: After matching, 1455 ACDF and 485 CDA cases were analyzed. Obese patients undergoing ACDF had significantly higher nonroutine discharge rates (11.3% vs. 4.1%, = 0.037). ACDF patients had lower total costs ($16,400 vs. $19,400, = 0.003), with similar LOS (1.4 ± 0.1 days, = 0.931) and adverse event rates (7.6% vs. 8.2%, P = 0.827).
Conclusions: Obese patients undergoing ACDF experience higher nonroutine discharge rates compared to those receiving CDA. While CDA is associated with higher costs, it may offer superior discharge outcomes in this high-risk population.
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http://dx.doi.org/10.4103/jcvjs.jcvjs_108_25 | DOI Listing |
Curr Atheroscler Rep
September 2025
Division of Gastroenterology and Hepatology, Lynda K. and David M. Underwood Center for Digestive Health, Houston Methodist Hospital, Houston, TX, USA.
Purpose Of Review: This review aims to characterize the known cardiovascular (CV) manifestations associated with inflammatory bowel disease (IBD) and the underlying mechanisms driving these associations.
Recent Findings: Gut dysbiosis, a hallmark of patients with IBD, can result in both local and systemic inflammation, thereby potentially increasing the risk of cardiovascular disease (CVD) in the IBD population. Micronutrient deficiencies, anemia, and sarcopenia independently increase the risk of CVD and are frequent comorbidities of patients with IBD.
Rev Med Suisse
August 2025
Service de gastroentérologie et d'hépatologie, Département de médecine, Hôpitaux universitaires de Genève, 1211 Genève 14.
The treatment of metabolic dysfunction-associated steatotic liver disease involves physical activity, weight loss, and management of comorbidities (diabetes, hypertension, dyslipidemia). In 2024, the American Food and Drug Administration provisionally approved resmetirom for metabolic dysfunction-associated steatohepatitis. Other promising molecules are being evaluated (glucagon-like peptide 1 receptor agonists, fibroblast growth factor 21 agonist).
View Article and Find Full Text PDFSpine (Phila Pa 1976)
October 2025
Department of Orthopaedic Surgery, Rothman Orthopaedic Institute at Thomas Jefferson University Hospital, Philadelphia, PA.
Study Design: Retrospective cohort.
Objective: To evaluate the impact of having a history of obstructive sleep apnea (OSA) in patients undergoing anterior cervical discectomy and fusion (ACDF) on postoperative outcomes.
Background: With an aging population and rates of obesity increasing, comorbidities that influence patient safety are increasingly common.
Cancer
September 2025
Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Background: The influence of obesity and sex on outcomes in pancreatic adenocarcinoma (PDAC) remains unclear. The association between obesity (body mass index [BMI], ≥30) and biologic sex (male or female) for outcomes in patients with PDAC undergoing a surgery-first approach was investigated.
Methods: A prospectively maintained pancreatic cancer database at the Memorial Sloan Kettering Cancer Center was queried to identify all patients undergoing surgery with a pathologic diagnosis of PDAC.