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Article Abstract
Clear iodine-131 (I)-6-β-iodomethyl- norcholesterol aldosterinoma finding, proven on biopsy, without prior discontinuation of spironolactone (due to high blood pressure) reveals no changes on scintigraphic sensitivity.
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Usefulness and reliability of I-6-β-iodomethyl- norcholesterol (NP-59), adrenal cortex scintigraphy in discrimination between adenoma and hyperplasia in case of a patient with primary hyperaldosteronism (PH) without discontinuation of antihypertension therapy.
Hell J Nucl Med
August 2025
Department of Nuclear Medicine, Sotiria Hospital, Athens Greece.
Clear iodine-131 (I)-6-β-iodomethyl- norcholesterol aldosterinoma finding, proven on biopsy, without prior discontinuation of spironolactone (due to high blood pressure) reveals no changes on scintigraphic sensitivity.
View Article and Find Full Text PDF[I]6ß-Iodomethyl-19-norcholesterol SPECT/CT for the Lateralization of Mineralocorticoid Overproduction in Primary Aldosteronism.
Diagnostics (Basel)
September 2024
Division of Endocrinology, Department of Internal Medicine, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary.
Unlabelled: Primary: aldosteronism is a frequent cause of secondary hypertension. With access to specialized care, an increasing number of patients with aldosteronism are being identified. Primary aldosteronism is treatable by adrenal surgery if aldosterone excess originates from one of the two, and not from both, adrenals.
View Article and Find Full Text PDFDiagnostic Accuracy of Adrenal Iodine-131 6-Beta-Iodomethyl-19-Norcholesterol Scintigraphy for the Subtyping of Primary Aldosteronism.
Biomedicines
July 2023
Endocrinology & Nutrition Department, Hospital Clinic, IDIPAS, 08007 Barcelona, Spain.
Purpose: To evaluate the diagnostic accuracy of the 131I-6β-iodomethyl-19-norcholesterol (NP-59) adrenal scintigraphy for the subtyping diagnosis of primary aldosteronism (PA), considering as gold standard for the diagnosis of unilateral PA (UPA), either the results of the adrenal venous sampling (AVS) or the outcome after adrenalectomy.
Methods: A retrospective multicenter study was performed on PA patients from 14 Spanish tertiary hospitals who underwent NP-59 scintigraphy with an available subtyping diagnosis. Patients were classified as UPA if biochemical cure was achieved after adrenalectomy or/and if an AVS lateralization index > 4 with ACTH stimulation or >2 without ACTH stimulation was observed.
Effect of Obesity on Clinical Characteristics of Primary Aldosteronism Patients at Diagnosis and Postsurgical Response.
J Clin Endocrinol Metab
December 2023
Endocrinology & Nutrition Department, Instituto de Investigación Biomédica Ramón y Cajal (IRYCIS), Hospital Universitario Ramón y Cajal, 28034 Madrid, Spain.
Context: Patients with obesity have an overactivated renin-angiotensin-aldosterone system (RAAS) that is associated with essential hypertension. However, the influence of obesity in primary aldosteronism (PA) is unknown.
Objective: We analyzed the effect of obesity on the characteristics of PA, and the association between obesity and RAAS components.
Strategies for subtyping primary aldosteronism.
J Formos Med Assoc
March 2024
Faculty of Medicine, National Yang Ming Chiao Tung University School of Medicine, Taipei, Taiwan; Section of Endocrinology and Metabolism, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.
Article Synopsis
- - Adrenal venous sampling (AVS) is a key procedure for identifying the side of primary aldosteronism (PA) and should be performed after stopping antihypertensive medications and correcting low potassium levels.
- - Hospitals conducting AVS are encouraged to create their own diagnostic guidelines, and if medications can't be stopped, the procedure can still be conducted if serum renin levels are low.
- - To improve AVS success, a combination approach using hormone stimulation tests and imaging techniques is recommended, with an NP-59 scan as a backup option for cases where AVS fails, especially for patients considering surgery for unilateral PA.