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Digital health interventions are increasingly used to promote behaviour change in adolescents. The Living Lab approach, fostering collaboration with users and stakeholders to identify real-life problems and co-create sustainable solutions, is gaining traction in health interventions. This study aimed to evaluate the usability of a novel Digital-based Living Lab (D-LLab) designed to promote healthy dietary behaviour in adolescents. The D-LLab was developed in four phases: topic derivation, strategy selection, digital tool selection, and usability assessment. It was implemented over a 4-week period, structured into four participatory phases: identifying problems, exploring solutions, solving problems, and sharing outcomes. Twenty-one adolescents aged 14-16 from one middle school enrolled, with a balanced sample of racial and ethnic adolescents, and native Koreans. Usability was evaluated using a mixed methods approach, incorporating quantitative indicators-appropriateness (system usability scale, SUS), acceptability (satisfaction), and feasibility (completion rate)-alongside qualitative data on participant experiences. The mean SUS score was 70.75, exceeding the benchmark for acceptable usability. Participants rated high satisfaction (mean score: 8.45/10), and 95.2% completed all sessions. High usability appeared to be driven by real-time information sharing and collaborative digital interaction, which supported spontaneous problem solving around dietary issues. The D-LLab demonstrated acceptable usability and strong participant engagement. These findings highlight the feasibility of applying digital-based Living Lab approaches in school settings, warranting further trials to evaluate long-term behavioural impact across diverse populations. This intervention was registered at cris.nih.go.kr as KCT0007004.
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http://dx.doi.org/10.1093/eurpub/ckaf129 | DOI Listing |
CNS Drugs
September 2025
Global Health Neurology Lab, Sydney, NSW, 2150, Australia.
Acute ischemic stroke (AIS) remains a leading cause of mortality and long-term disability globally, with survivors at high risk of recurrent stroke, cardiovascular events, and post-stroke dementia. Statins, while widely used for their lipid-lowering effects, also possess pleiotropic properties, including anti-inflammatory, endothelial-stabilizing, and neuroprotective actions, which may offer added benefit in AIS management. This article synthesizes emerging evidence on statins' dual mechanisms of action and evaluates their role in reducing recurrence, improving survival, and mitigating cognitive decline.
View Article and Find Full Text PDFNurs Res
September 2025
College of Nursing & Institute of Nursing Research, Korea University, Seoul, South Korea.
Background: Existing research fails to address the complex nature of nonspecific chronic lower back pain (cLBP ) despite its detrimental effect on economic, societal, and medical expenditures.
Objectives: We developed a nurse-led, mobile-delivered self-management intervention-Problem-Solving Pain to Enhance Living Well (PROPEL-M)-and evaluated its usability, feasibility, and initial efficacy for South Korean adults with nonspecific cLBP.
Methods: This study was composed of two phases: (a) lab and field usability testing for a gamified mobile device application; and (b) a pilot study employing a one-arm pre-test and post-test design among adults aged 18-60 years with nonspecific cLBP.
Small Methods
September 2025
Institute of Geriatrics (Shanghai University), Affiliated Nantong Hospital of Shanghai University (The Sixth People's Hospital of Nantong) and School of Life Science, Shanghai University, Nantong, 226011, China.
Timely blood resupply is a clinical strategy to treat myocardial infarction, which unavoidably causes myocardial ischemia-reperfusion injury. With disturbed electrical conduction and oxidative stress in infarcted myocardium, injured heart experiences a negative ventricle remodeling process, and finally leads to heart failure. Nitric oxide (NO) is a short-lived signaling molecule regulating cardiovascular homeostasis, while vasodilation of systemic vasculature is accompanied by its exogenous supplementation.
View Article and Find Full Text PDFProc Natl Acad Sci U S A
September 2025
Department of Integrative Biology, University of California, Berkeley, CA 94720-3140.
Microscale symbioses can be critical to ecosystem functions, but the mechanisms of these interactions in nature are often cryptic. Here, we use a combination of stable isotope imaging and tracing to reveal carbon (C) and nitrogen (N) exchanges among three symbiotic primary producers that fuel a salmon-bearing river food web. Bulk isotope analysis, nanoSIMS (secondary ion mass spectrometry) isotope imaging, and density centrifugation for quantitative stable isotope probing enabled quantification of organism-specific C- and N-fixation rates from the subcellular scale to the ecosystem.
View Article and Find Full Text PDFJ Appl Gerontol
September 2025
Division of Social Welfare, Kangnam University, Yongin-si, Korea.
Welfare technology is becoming essential for promoting older adults' well-being, reducing health risks, and enhancing social engagement. While many welfare technology living lab studies focus on single devices, integrating multiple digital tools may offer greater emotional and cognitive benefits. This study investigates the effects of a living lab-based intervention using two digital devices: one targeting cognitive function (D1) and the other targeting physical function (D2).
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