Visible-Light-Driven Trifluoroacetylation of Azauracils.

A novel visible-light-driven method for the trifluoroacetylation of azauracils was reported, utilizing oxygen as the oxidant and a masked trifluoroacetyl reagent as the radical precursor. This eco-friendly approach eliminates the need for expensive catalysts, transition metals, and additional additives, offering a straightforward, efficient, and scalable solution. The method demonstrates excellent functional group tolerance and versatility, making it ideal for late-stage modifications of a wide range of bioactive molecules. This advancement not only improves the synthetic accessibility of trifluoroacetylated compounds but also supports the principles of sustainable chemistry.