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We investigate the dynamics of active paths during a two-phase flow of immiscible fluids under an external pressure drop ΔP. We demonstrate that this dynamics of new path opening plays a crucial role in understanding the nonlinear rheology for the one-dimensional capillary fiber bundle model in the limit where the capillary forces are comparable with the viscous forces. The contribution of gradual path-opening dynamics is controlled by tuning maximum value of the capillary thresholds (P_{M}) around which one observes the following situation: flow through existing paths plus new path opening for ΔP
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http://dx.doi.org/10.1103/PhysRevE.111.065102 DOI Listing Publication Analysis
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Front Artif Intell
August 2025
School of Computation and Communication Science and Engineering, The Nelson Mandela African Institution of Science and Technology, Arusha, Tanzania.
Computer vision has been identified as one of the solutions to bridge communication barriers between speech-impaired populations and those without impairment as most people are unaware of the sign language used by speech-impaired individuals. Numerous studies have been conducted to address this challenge. However, recognizing word signs, which are usually dynamic and involve more than one frame per sign, remains a challenge.
View Article and Find Full Text PDFMed Int (Lond)
August 2025
Hunan Provincial Hospital of Integrated Traditional Chinese and Western Medicine (The Affiliated Hospital of Hunan Academy of Traditional Chinese Medicine), Changsha, Hunan 410060, P.R. China.
S-glutathionylation (SSG), a redox-sensitive post-translational modification mediated by glutathione, regulates protein structure and function through reversible disulfide bond formation at cysteine residues. Glutaredoxins (GRXs), pivotal antioxidant enzymes, catalyze SSG dynamics to maintain thiol homeostasis. Recent advances in redox proteomics have revealed that SSG dysregulation is intricately linked to neurodegenerative, cardiovascular, pulmonary and malignant diseases.
View Article and Find Full Text PDFiScience
September 2025
Department of Neurosurgery, University of Alabama at Birmingham, Birmingham, AL, USA.
Goal-directed behavior requires adjusting cognitive control, both in preparation for and in reaction to conflict. Theta oscillations and population activity in dorsomedial prefrontal cortex (dmPFC) and dorsolateral PFC (dlPFC) are known to support reactive control. Here, we investigated their role in proactive control using human intracranial electroencephalogram (EEG) recordings during a Stroop task that manipulated conflict expectations.
View Article and Find Full Text PDFBiochem Biophys Rep
December 2025
Henan University of Chinese Medicine, Zhengzhou, 450046, China.
Introduction: 5-Hydroxymethyl furfural (5-HMF) is a furan compound with a molecular formula of CHO. Studies have found that 5-HMF has many pharmacological effects, such as improving hemorheology, anti-inflammatory, antioxidant activity and anti-myocardial ischemia. Identifying the preventive effect of 5-HMF against ischemic stroke and its possible mechanism was the aim of this investigation.
View Article and Find Full Text PDFInt J Nanomedicine
September 2025
Department of Pharmaceutics and Pharmaceutical Technology, Universitas Padjadjaran, Sumedang, West Java, 45363, Indonesia.
Background: Candidiasis, predominantly caused by , poses a significant global health challenge, especially in tropical regions. Nystatin is a potent antifungal agent that is hindered by its low solubility and permeability, limiting its clinical efficacy.
Methods: This study aimed to investigate the potential of a layer-by-layer (LBL) coating system, employing chitosan and alginate, to improve the stability, entrapment efficiency (%EE), and antifungal efficacy of nystatin-loaded liposomes against Candida albicans.