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Accurate identification and segmentation of brain tumors in Magnetic Resonance Imaging (MRI) images are critical for timely diagnosis and treatment. MRI is frequently used to diagnose these disorders; however medical professionals find it challenging to manually evaluate MRI pictures because of time restrictions and unpredictability. Computerized methods such as R-CNN, attention models and earlier YOLO variants face limitations due to high computational demands and suboptimal segmentation performance. To overcome these limitations, this study proposes a successive framework that evaluates YOLOv9, YOLOv10, and YOLOv11 for tumor detection and segmentation using the Figshare Brain Tumor dataset (2100 images) and BraTS2020 dataset (3170 MRI slices). Preprocessing involves log transformation for intensity normalization, histogram equalization for contrast enhancement, and edge-based ROI extraction. The models were trained on 80% of the combined dataset and evaluated on the remaining 20%. YOLOv11 demonstrated superior performance, achieving 96.22% classification accuracy on BraTS2020 and 96.41% on Figshare, with an F1-score of 0.990, recall of 0.984, mAP@0.5 of 0.993, and mAP@ [0.5:0.95] of 0.801 during testing. With a fast inference time of 5.3 ms and a balanced precision-recall profile, YOLOv11 proves to be a robust, real-time solution for brain tumor detection in clinical applications.
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http://dx.doi.org/10.1038/s41598-025-13155-4 | DOI Listing |
J Neurooncol
September 2025
Institute of Medical Biostatistics, Epidemiology, and Informatics (IMBEI), University Medical Center Mainz, Mainz, Germany.
Purpose: Patients diagnosed with high-grade gliomas (HGG) often experience substantial psychosocial dis-tress. However, due to neurological and neurocognitive deficits its assessment remains challenging, and needs remain unmet. We compared a novel face-to-face assessment during doctor-patient conversations with questionnaire-based screening.
View Article and Find Full Text PDFBiochem Genet
September 2025
Department of Medical Biology, Cerrahpasa Faculty of Medicine, Istanbul University Cerrahpasa, Kocamustafapasa, 34098, Istanbul, Turkey.
Glioblastoma is the most aggressive and malignant tumor of the central nervous system. Current treatment options, including surgical excision, radiotherapy, and chemotherapy, have Limited efficacy, with a median survival rate of approximately 15 months. To develop novel therapeutics, it is crucial to understand the underlying molecular mechanisms driving glioblastoma.
View Article and Find Full Text PDFStroke Vasc Neurol
September 2025
Department of Neurology, Sun Yat-Sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China
Rationale: Radial artery spasm (RAS) is a common complication during transradial cerebral angiography (TRA), but currently, the optimal prevention strategy is not well established. Papaverine has anti-vasospasm, sedative and analgesic effects. However, the efficacy of papaverine in preventing RAS during TRA remains unknown.
View Article and Find Full Text PDFBMJ Health Care Inform
September 2025
Center for Sleep and Circadian Medicine, The Affiliated Brain Hospital, Guangzhou Medical University, Guangzhou, Guangdong, China
Objectives: The objectives were to examine the associations between accelerometer-measured circadian rest-activity rhythm (CRAR), the most prominent circadian rhythm in humans and the risk of mortality from all-cause, cancer and cardiovascular disease (CVD) in patients with cancer.
Methods: 7456 cancer participants from the UK Biobank were included. All participants wore accelerometers from 2013 to 2015 and were followed up until 24 January 2024, with a median follow-up of 9.
Brain Res
September 2025
Department of Pathology, Xinxiang Medical University, Xinxiang, China. Electronic address:
Glioma is a malignant brain tumor in which the lncRNA ENSG00000232259 is significantly upregulated. Bioinformatics predictions suggest that it may encode the polypeptide ENSG00000232259-ORF, but the biological function and mechanisms of this polypeptide in glioma remain unclear. Gene expression and correlation analyses were conducted using the GEPIA database, combined with GetORF to predict the polypeptide-coding potential, and Western blot was employed to validate the expression of ENSG00000232259-ORF.
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