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Background: Sarcopenia is a key modifiable risk factor for falls in older adults with a history of falls. However, its diagnosis is a challenge owing to limited resources in primary care or community settings. In 2019, the Asian Working Group for Sarcopenia introduced the concept of 'possible sarcopenia' as an easily accessible diagnostic criterion for at-risk individuals. This study aimed to explore factors associated with possible sarcopenia in older adults with a history of falls.
Methods: A cross-sectional study was conducted among 211 older adults aged 65 years and older with at least one fall in the past two years. Possible sarcopenia was identified using a stepwise approach: participants with low calf circumference (< 34 cm for men, < 33 cm for women) underwent further assessments of muscle strength (handgrip strength) and physical performance (5-time chair stand test). Those with low calf circumference along with either low muscle strength (< 28 kg for men, < 18 kg for women) or poor physical performance (≥ 12 s) were classified as having possible sarcopenia. Multiple logistic regression analysis was performed to identify factors associated with possible sarcopenia.
Results: Among the older adults with a history of falls, 27.5% were identified as having possible sarcopenia. Significantly associated factors included older age (≥ 75 years), living alone, unemployment, and depressive symptoms, whereas sex, alcohol consumption, smoking, recurrent falls, and the fear of falling were not significant.
Conclusions: Possible sarcopenia is common in older adults with a history of falls and is significantly associated with advanced age, living alone, unemployment, and depressive symptoms. Therefore, early screening and targeted multifaceted interventions are crucial in mitigating sarcopenia.
Clinical Trial Number: Not applicable.
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http://dx.doi.org/10.1186/s12877-025-06248-2 | DOI Listing |
Haematologica
September 2025
Center for Cardiometabolic Science, Christina Lee Brown Envirome Institute, Division of Environmental Medicine, Department of Medicine, University of Louisville, Louisville, Kentucky,.
Maintaining a healthy pool of circulating red blood cells (RBCs) is essential for adequate perfusion, as even minor changes in the population can impair oxygen delivery, resulting in serious health complications including tissue ischemia and organ dysfunction. This responsibility largely falls to specialized macrophages in the spleen, known as red pulp macrophages, which efficiently take up and recycle damaged RBCs. However, questions remain regarding how these macrophages are acutely activated to accommodate increased demand.
View Article and Find Full Text PDFHaematologica
September 2025
Division of Hematology, Jichi Medical University Saitama Medical Center, Saitama, Japan; Division of Hematology, Department of Medicine, Jichi Medical University, Shimotsuke.
Patient age might influence donor selection priorities in allogeneic hematopoietic stem cell transplantation (allo-HCT), due to the differences in donor age, organ function, and resistance to graft-versus-host disease between younger and older patients. We compared the transplant outcomes among human leukocyte antigen (HLA)-matched related donors (M-RDs, n=4,106), HLA 1-antigen-mismatched related donors (1MM-RDs, n=592), HLA 2-3-antigen-mismatched related donors (23MM-RDs, n=882), HLA-matched unrelated donors (M-UDs, n=3,927), HLA 1-locus-mismatched unrelated donors (1MM-UDs, n=2,474), and unrelated cord blood units (U-CBs, n=5,867) between patients aged.
View Article and Find Full Text PDFHypertension
September 2025
Department of Hypertension, Center for Epidemiological Studies and Clinical Trials, the Shanghai Institute of Hypertension, Shanghai Key Laboratory of Hypertension, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, China (J.W.).
Background: The association between season of screening blood pressure (BP) measurement and adverse outcomes has not been examined among populations without prior physician-diagnosed hypertension. We aimed to investigate the association between the season of screening clinic BP measurement and the risk of all-cause mortality.
Methods: This was a prospective cohort study, and data were analyzed from an ongoing community hypertension screening program in Shanghai between 2018 and 2024.
Emerg Med Australas
October 2025
Emergency and Trauma Centre, The Alfred Hospital, Melbourne, Victoria, Australia.
Objectives: Acute pyelonephritis (APN) is a common diagnosis among patients presenting to the Emergency Department (ED). It is treated by empiric antibiotics within the ED. With a rise in antimicrobial resistance globally, it is unknown whether patients are being managed with empiric antibiotics that are appropriate for the causative organisms of APN.
View Article and Find Full Text PDFEmerg Med Australas
October 2025
Australian Centre for Health Services Innovation, School of Public Health & Social Work, Queensland University of Technology, Brisbane, Queensland, Australia.
Reliably defining the risk of adverse in-flight events in aeromedical trauma patients could enable more informed pre-departure treatment and guide central asset allocation to achieve better system-level outcomes. Unfortunately, the current literature base specifically examining the in-flight period is sparse. Flight duration is often considered a proxy for the risk of in-flight deterioration; however, there is limited data to support this commonly held assumption.
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