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Article Abstract
There is well reasoned enthusiasm for osteochondral allograft (OCA) transplantation as a treatment for full thickness chondral lesions in the knee. Previous literature has demonstrated that the success of this operation is largely predicated upon successful osseous integration at the graft-recipient site interface. The soaking of OCA grafts in either platelet rich plasma (PRP) or bone marrow aspirate concentrate (BMAC) has been proposed as a method for enhancing the osteoinductive potential of the healing environment, ultimately, for improving clinical outcomes. However, the results of this approach have been mixed and, the utility of orthobiologic therapies as adjuncts to OCA transplantation has yet to be proven in a prospective, comparative trial. Based upon the results of the current study, the addition of BMAC may decrease the likelihood of large cystic changes at the graft-recipient site interface.
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| http://dx.doi.org/10.1016/j.arthro.2025.07.025 | DOI Listing |
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There is well reasoned enthusiasm for osteochondral allograft (OCA) transplantation as a treatment for full thickness chondral lesions in the knee. Previous literature has demonstrated that the success of this operation is largely predicated upon successful osseous integration at the graft-recipient site interface. The soaking of OCA grafts in either platelet rich plasma (PRP) or bone marrow aspirate concentrate (BMAC) has been proposed as a method for enhancing the osteoinductive potential of the healing environment, ultimately, for improving clinical outcomes.
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