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Regional blocks are effective adjuncts in autologous breast reconstruction. Data on specific regional blocks and agents remain unclear.We performed a retrospective review of patients who underwent abdominal free flap breast reconstruction between July 2017 and June 2022. A total of 256 patients were included with 181 who received Exparel transversus abdominis plane (TAP) blocks, 54 with non-Exparel TAP blocks, and 21 without a TAP block. Length of stay (LOS), intensive care unit length of stay (ICU LOS), average daily morphine milligram equivalents (MME), and average total MME were collected.Comparing the Exparel TAP block cohort and non-Exparel TAP block cohort, there was no difference in LOS (2.71 vs. 2.72 days, = 0.96), ICU LOS (0.35 vs. 0.56 days, = 0.18), daily MME (29.08 vs. 29.71 MME, = 0.85), and total MME (113.69 vs. 113.92 MME, = 0.99). Comparing the Exparel TAP block cohort and non-TAP block cohort, there were significant differences in LOS (2.71 vs. 3.62 days, = 0.003), ICU LOS (0.35 vs. 1.1 days, = 0.001), daily MME (29.08 vs. 39.56, = 0.04), and total MME (113.69 vs. 195.55, = 0.001). When comparing the non-Exparel TAP block cohort and the non-TAP block cohort, there were differences in LOS (2.72 vs. 3.62 days, = 0.004), ICU LOS (0.56 vs. 1.1 days, = 0.04), and total MME (113.92 vs. 195.55 MME, = 0.006).TAP block can effectively reduce the LOS and postoperative narcotic use in patients undergoing autologous breast reconstruction regardless of the choice of local anesthetic.
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http://dx.doi.org/10.1055/a-2671-7296 | DOI Listing |
Exp Clin Transplant
August 2025
>From Akdeniz University Medical Faculty, Department of Anesthesiology and Reanimation, Antalya, Türkiye.
Objectives: Postoperative donor care is being improved with newly applied methods. Recently, because of its effectiveness, erector spinae plane blocks have been increasing in popularity. However, its use for laparoscopic living-donor nephrectomy is not fully known.
View Article and Find Full Text PDFJ Intensive Care
September 2025
German Center for Vertigo and Balance Disorders, Ludwig-Maximilians-Universitat (LMU), University Hospital Grosshadern, Munich, Germany.
Background: Survivors of critical illness frequently face physical, cognitive and psychological impairments after intensive care. Sensorimotor impairments potentially have a negative impact on participation. However, comprehensive understanding of sensorimotor recovery and participation in survivors of critical illness is limited.
View Article and Find Full Text PDFAnn Transplant
September 2025
Department of Anesthesiology and Reanimation, Gazi Yaşargil Training and Research Hospital, Diyarbakır, Turkey.
BACKGROUND Among the limited analgesic options, plane blocks are of great importance in providing effective postoperative analgesia to donors and recipients in renal transplantation surgery. We aimed to demonstrate that anterior type quadratus lumborum plane block provides better analgesia than intravenous paracetamol in open and closed nephrectomy patients. MATERIAL AND METHODS We conducted a prospective cohort study.
View Article and Find Full Text PDFJ Thorac Cardiovasc Surg
September 2025
Deparment of Thoracic and Cardiovascular Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea. Electronic address:
Objective: To evaluate the impact of CT planning on surgical myectomy outcomes in patients with hypertrophic cardiomyopathy (HCM) and left ventricular outflow tract (LVOT) and/or mid-cavity obstruction, by comparing these outcomes with those of conventional surgical myectomy.
Methods: This prospective cohort study included patients who underwent surgical septal myectomy for HCM with LVOT and/or mid-cavity obstruction between January 2019 and May 2024 at a single tertiary center. In the CT-planned myectomy group, an expert radiologist simulated the target myectomy site through a series of post-processing methods to plan the surgical approach, provide a surgeon's view that closely resembles the actual perspective in the operating room, and present the target myectomy volume.
ESMO Open
September 2025
Aminex Therapeutics, Inc., Kenmore, USA. Electronic address:
Background: Dysregulation of polyamine synthesis has been observed in various cancer cell types. A novel approach to depriving cancer cells of polyamines involves the use of difluoromethylornithine (DFMO) to block polyamine biosynthesis in combination with AMXT 1501, a potent inhibitor of polyamine transport. Preclinical mouse tumor models showed that the combination of AMXT 1501 plus DFMO had strong antitumor activity, together with evidence of a stimulated immune response against tumors.
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