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http://dx.doi.org/10.1097/MAT.0000000000002526 | DOI Listing |
J Am Heart Assoc
September 2025
KHP Centre for Translational Medicine, King's College London British Heart Foundation, Cardiovascular Division, Department of Clinical Pharmacology St Thomas' Hospital London United Kingdom.
Background: The aim of this study was to investigate the associations between pulse pressure (PP) and age-related structural brain changes including brain volumes, white matter hyperintensities (WMH), fractional anisotropy, silent brain lesions, microbleeds, cerebral blood flow and metabolism, and beta-amyloid accumulation.
Methods: Systematic review of PubMed (MEDLINE), Scopus, and Ovid Embase (from inception to January 2023) and references of included studies among adult populations was conducted. Findings were summarized narratively and by performing a fixed-effects meta-analysis.
J Clin Epidemiol
September 2025
Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.
Objective: It is widely recognised that selective reporting clinical trial results based on their outcomes, in the forms of publication bias, outcome reporting bias, or p-hacking, has detrimental effects on the scientific literature and on evidence synthesis. This can be recognised, and perhaps ameliorated with comprehensive trial registration. However, previous investigations of clinical trial registration focussed on study-level examinations, rather than the number of trial participants, which is often more relevant to meta-analysis.
View Article and Find Full Text PDFEBioMedicine
August 2025
Ifakara Health Institute, Bagamoyo, Tanzania; Swiss Tropical and Public Health Institute, Allschwil, Switzerland.
Background: Volatile pyrethroid spatial repellents (VPSRs) can prevent mosquito-borne diseases including malaria and dengue fever, but the use of varied evaluation methods has resulted in a lack of clarity regarding their protective efficacy (PE) against contact with mosquitoes. This systematic review and meta-analysis consolidates the entomological evidence base on the PE of VPSRs against Anopheles, Aedes, and Culex mosquitoes and different test methods used.
Methods: We identified studies completed between January 2000 and September 2023 by searching through databases, conference abstracts, and personal correspondences.
Intern Emerg Med
August 2025
Department of Emergency Medicine and Trauma, Indira Gandhi Medical College and Research Institute, Kathirkamam, Puducherry, India.
Intermediate-risk pulmonary embolism (IRPE) is a critical clinical entity with significant mortality risk due to normotensive shock, a condition marked by low cardiac index despite maintained blood pressure. Accurate and timely detection of hemodynamic compromise in IRPE remains a challenge. Velocity Time Integral (VTI), a Doppler echocardiographic parameter, has emerged as a potential non-invasive tool for predicting hospital outcomes, but the evidence remains fragmented.
View Article and Find Full Text PDFHum Reprod Update
August 2025
Monash Centre for Health Research and Implementation, Monash University, Clayton, Australia.
Background: The time before conception is an important opportunity to improve maternal lifestyle, and hence improve fertility and health. However, the components of effective preconception lifestyle interventions are unclear.
Objective And Rationale: This review aimed to assess the association of intervention characteristics and behaviour change techniques with the effect of lifestyle interventions on fertility, obstetric, foetal, anthropometric, and metabolic outcomes in women planning a pregnancy.