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Article Abstract
Background: Community viral load (CVL) is defined as an aggregate measure of individual viral loads of people living with HIV who are receiving care in a specific community. It serves as a metric to evaluate the effectiveness of therapy programs. Our study aimed to analyze the overtime trend and the distribution characteristics of viral load.
Methods: Using the Lorenz curve, we investigated the demographic characteristics of individuals who comprised the top 10% of viral loads over the years. We applied the Gini index to measure the inequality in the distribution of viral load among the study population.
Results: Our data showed a progressive decrease in community viral load over the years, with a sharp decline after 2012 and a rebound in 2020. The Gini index had a specular trend during this period. In all the observed periods, the top 10% of viral loads showed a progressive increase in the proportion of female individuals and non-Italian nationals.
Conclusion: Our study highlighted the effectiveness and the improvement of the HIV care cascade over the years, with a decrease in community HIV viral load. The introduction of integrase inhibitors seemed to cause a rapid drop in community viral load in 2012 but with a notable discrepancy in the homogeneity of the population. It is also important to highlight the changes over time in the population representing the top 10% of viral loads, with a gradual but stable increase in the proportion of female and non-Italian individuals.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12307317 | PMC |
| http://dx.doi.org/10.3389/fpubh.2025.1580633 | DOI Listing |
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