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Less than 10% of primary hyperparathyroidism (PHPT) patients have supernumerary parathyroid glands. In a 52-year-old man with multiple endocrine neoplasia type 1 (MEN 1) syndrome with PHPT, integrated 18F-Fluorocholine PET/4D-CT (FCH PET/4D-CT) was done for localization of parathyroid adenoma. FCH PET/4D-CT revealed 5 culprit lesions (1 ectopic) along with FCH avid nonenhancing anterior mediastinal mass, possibly NET or thymoma. FNAC of the mass raised a suspicion of NET, which was corroborated by subsequent 68Ga-DOTANOC PET/CT. Parathyroidectomy for all 5 glands and thymic mass excision was done. Histopathology confirmed 5 hyperplastic parathyroid lesions and a well-differentiated thymic NET. Intact PTH and calcium levels were normalized postsurgery.
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http://dx.doi.org/10.1097/RLU.0000000000006067 | DOI Listing |
Clin Nucl Med
July 2025
Departments of Nuclear Medicine.
Less than 10% of primary hyperparathyroidism (PHPT) patients have supernumerary parathyroid glands. In a 52-year-old man with multiple endocrine neoplasia type 1 (MEN 1) syndrome with PHPT, integrated 18F-Fluorocholine PET/4D-CT (FCH PET/4D-CT) was done for localization of parathyroid adenoma. FCH PET/4D-CT revealed 5 culprit lesions (1 ectopic) along with FCH avid nonenhancing anterior mediastinal mass, possibly NET or thymoma.
View Article and Find Full Text PDFJCEM Case Rep
July 2025
Medical School, University of Western Australia, Nedlands, WA 6009 Australia.
A 53-year-old female patient was incidentally found to have asymptomatic hypercalcemia, later diagnosed due to primary hyperparathyroidism (PHPT): ionized calcium 6.48 mg/dL (SI: 1.62 mmol/L) (reference range, 4.
View Article and Find Full Text PDFInt J Surg Case Rep
June 2025
Faculty of Medical Sciences, Lebanese University, Hadath Campus, Lebanon; Department of General Surgery, Lebanese Hospital Geitaoui University Medical Center, Lebanon.
Introduction: Primary hyperparathyroidism (PHPT) is the most common cause of hypercalcemia and has shifted from a rare condition to a common endocrine disorder. Advances in diagnostic methods have led to more incidental diagnoses, particularly in asymptomatic patients. Ectopic parathyroid adenomas are a rare cause of PHPT, with the vast majority of cases involving parathyroid glands in typical anatomical locations.
View Article and Find Full Text PDFAm J Otolaryngol
May 2025
Department of Surgery, Royal College of Surgeons in Ireland (RCSI) University of Medicine and Health Sciences, Dublin, Ireland; Department of Surgery, Beaumont Hospital, Dublin, Ireland.
Objective: The aim of this systematic review was to investigate the value of intraoperative parathyroid hormone (IOPTH) monitoring in parathyroidectomy for tertiary hyperparathyroidism (THPT) to predict cure and recurrence.
Data Sources: Ovid, Embase, EBSCO Host, Citation Checking.
Methods: This study was performed in accordance with PRISMA guidelines.
Diagnostics (Basel)
December 2024
Department of Nuclear Medicine and Molecular Imaging, Institut de Cancérologie de Strasbourg Europe (ICANS), University Hospitals of Strasbourg, University of Strasbourg, 67200 Strasbourg, France.
Patients diagnosed with multiple endocrine neoplasia type-1 (MEN1) often initially present with primary hyperparathyroidism (pHPT), and typically undergo surgical intervention. While laboratory tests are fundamental for diagnosis, imaging is crucial for localizing pathological parathyroids to aid in precise surgical planning. In this pictorial review, we will begin by comprehensively examining key imaging techniques and their established protocols, evaluating their effectiveness in detecting abnormal parathyroid glands.
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