Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Identification of therapeutic vulnerabilities in cancer remains a high priority for cancer research. A recent CRISPR/Cas9 screen identified that VDAC2 deletion in tumors enhanced their sensitivity to interferon-γ (IFNγ) through the release of mitochondrial DNA (mtDNA) and activation of the cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway. These data suggest that VDAC2 inhibition could enhance antitumor therapies.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12352517 | PMC |
| http://dx.doi.org/10.1016/j.tips.2025.07.001 | DOI Listing |
Publication Analysis
Top Keywords
vdac2 brake
4
brake release
4
release unleashing
4
unleashing inflammation
4
inflammation ifnγ
4
ifnγ identification
4
identification therapeutic
4
therapeutic vulnerabilities
4
vulnerabilities cancer
4
cancer remains
4