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http://dx.doi.org/10.1007/s10928-025-09993-4 | DOI Listing |
Front Pharmacol
August 2025
Department of Pathogenic Biology and Key Laboratory of Tropical Translational Medicine of Ministry of Education, School of Basic Medicine and Life Sciences, Hainan Medical University, Haikou, China.
[This corrects the article DOI: 10.3389/fphar.2025.
View Article and Find Full Text PDFFront Psychiatry
July 2025
Department of Physiology, All India Institute of Medical Sciences, New Delhi, India.
Introduction: Rodent models are widely used to understand brain pathologies and address cognitive deficits experienced by humans diagnosed with clinical disorders. However, stark differences in the nervous system and in the environmental demands of rodents and humans make it difficult to translate insights from rodents to humans. Age and sex further increase vulnerability to disorders via experiences marked by neglect, deprivation, threat, and constraining environments instead of care, nutrition, safety, and enriching environment.
View Article and Find Full Text PDFJ Pharmacokinet Pharmacodyn
July 2025
Certara Predictive Technologies Division, Certara UK Ltd, Level 2-Acero, 1 Concourse Way, Sheffield, S1 2BJ, UK.
Sci Rep
May 2025
Institute of Plant Genetics, Breeding and Biotechnology, University of Life Sciences in Lublin, Akademicka Street 15, 20-950, Lublin, Poland.
PLoS Genet
March 2025
Department of Medicine, Section of Genetic Medicine, The University of Chicago, Chicago, Illinois, United States of America.
Genome-wide association studies (GWAS) have implicated specific alleles and genes as risk factors for numerous complex traits. However, translating GWAS results into biologically and therapeutically meaningful discoveries remains extremely challenging. Most GWAS results identify noncoding regions of the genome, suggesting that differences in gene regulation are the major driver of trait variability.
View Article and Find Full Text PDF