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Purpose: To verify and compare the response time, amplitude, and neural auditory maintenance of the central auditory pathway in subjects with and without tinnitus disorder.
Methods: This is an analytical, cross-sectional, and quantitative study approved by the Research Ethics Committee. The responses of Long Latency Auditory Evoked Potentials (LLAEP) with verbal stimuli were compared between 16 subjects with tinnitus disorder (Study Group - SG) and 12 subjects without tinnitus (Control Group - CG). The neural response time was evaluated by the latency of the P1, N1, P2, N2, and P300 potentials. The amplitude of these potentials was also analyzed. Neural response maintenance was verified through the duration values of the P300 component. The results were compared between the groups, considering a significance level of 5%.
Results: In the comparison between the groups regarding the latency and amplitude values of the cortical potentials (P1, N1, P2, and N2), no statistically significant differences were observed (p>0.05). However, concerning the latency, amplitude, and duration of the P300 component between the groups, a statistically significant difference was observed for the latency variable, which was greater for individuals with tinnitus disorder (p<0.05).
Conclusion: Individuals with tinnitus disorder have a longer neural response time for the P300 component, suggesting disorganization in central auditory processing.
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http://dx.doi.org/10.1590/2317-1782/e20240211pt | DOI Listing |
Autophagy
September 2025
Department of Biochemistry and Molecular Biology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Macroautophagy/autophagy is an evolutionarily conserved process through which cells degrade cytoplasmic substances via autophagosomes. During the initiation of autophagosome formation, the ULK/Atg1 complex serves as a scaffold that recruits and regulates downstream ATG/Atg proteins and ATG9/Atg9-containing vesicles. Despite the essential role of the ULK/Atg1 complex, its components have changed during evolution; the ULK complex in mammals consists of ULK1 (or ULK2), RB1CC1, ATG13, and ATG101, whereas the Atg1 complex in the yeast lacks Atg101 but instead has Atg29 and Atg31 along with Atg17.
View Article and Find Full Text PDFCirc Arrhythm Electrophysiol
September 2025
Department of Congenital Heart Disease, Evelina London Children's Hospital, United Kingdom (S. Chivers, T.V., V.Z., S.M., G.M., W.R., E.R., D.F.A.L., T.G.D., O.I.M., G.K.S., J.M.S.).
Background: Fetal tachycardias can cause adverse fetal outcomes including ventricular dysfunction, hydrops, and fetal demise. Postnatally, ECG is the gold standard, but, in fetal practice, echocardiography is used most frequently to diagnose and monitor fetal arrhythmias. Noninvasive extraction of the fetal ECG (fECG) may provide additional information about the electrophysiological mechanism and monitoring of intermittent arrhythmias.
View Article and Find Full Text PDFDiagn Interv Radiol
September 2025
Department of Internal Medicine, Biomedical Research Institute, Pusan National University Hospital, Pusan National University School of Medicine, Busan, Korea.
Purpose: To evaluate the feasibility of abbreviated liver magnetic resonance imaging (AMRI) with a second-shot arterial phase (SSAP) image for the viability of treated hepatocellular carcinoma (HCC) after non-radiation locoregional therapy (LRT).
Methods: We retrospectively enrolled patients with non-radiation LRT for HCC who underwent the modified gadoxetic acid-enhanced liver MRI protocol, which includes routine dynamic and SSAP imaging after the first and second injection of gadoxetic acid, respectively (6 mL and 4 mL, respectively), and an available reference standard for tumor viability in the treated HCC between March 2021 and February 2022. Two radiologists independently reviewed the full-protocol MRI (FP-MRI) and AMRI with SSAP.
Nanoscale
September 2025
Department of Physics, University of Oxford, Parks Road, Oxford, OX1 3PU, UK.
The mechanical properties of the polymeric substrate or matrix where a cell grows affect cell behavior. Most studies have focused on relating elastic properties of polymeric substrates, which are time-independent, to cell behaviors. However, polymeric substrates and biological systems exhibit a time-dependent, often viscoelastic, mechanical response.
View Article and Find Full Text PDFOrg Biomol Chem
September 2025
Universidad de Córdoba, Grupo de Química Computacional, Facultad de Ciencias Básicas, Carrera 6, No. 77-305, Montería-Córdoba, Colombia.
This study explores the photochemical conversion of BN-Dewar benzene into BN-benzvalene derivatives, offering a strategic route to heteroatom-containing valence isomers with distinctive electronic properties. Using time-dependent density functional theory (TD-DFT) and electron localization function (ELF) analyses, the excited-state mechanism and associated structural rearrangements were elucidated. Vertical excitation to the S state was found to weaken the CC and B-N bonds while strengthening the N-Si bond in silyl-substituted derivatives, a key factor enabling efficient BN-benzvalene formation.
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