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http://dx.doi.org/10.46747/cfp.710708448 | DOI Listing |
Methods Mol Biol
August 2025
Laboratory of Cell Signalling, Centre for DNA Fingerprinting and Diagnostics, Hyderabad, India.
Knockout mice have served as excellent model systems to investigate the functions of specific mammalian proteins at the organismal level. Several studies on tissue-specific or whole-body depletion of individual IP6 kinase (IP6K) paralogs have shed light on myriad roles for their product, the inositol pyrophosphate 5-InsP, in different physiological processes and pathological states. The loss of Ip6k1, Ip6k2, or Ip6k3 leads predominantly to nonoverlapping phenotypes in mice, reflecting their differential tissue, cell type, and subcellular distribution.
View Article and Find Full Text PDFHist Philos Life Sci
August 2025
Department of Zoology, University of Cambridge, Downing St., Cambridge, CB2 3EJ, UK.
Ronald Aylmer Fisher (1890-1962) was a pioneer of evolutionary biology who founded modern statistics. He has often been associated with a gene-centric conception of natural selection, but he did not discount the importance of factors operating at other levels. In the later chapters of his 1930 book, The Genetical Theory of Natural Selection, Fisher proposed a mechanism to explain how a human civilization of any ethnicity could rise or fall.
View Article and Find Full Text PDFJ Addict Nurs
August 2025
Amy Butz, PharmD, BCPP, Department of Pharmacy Services, Veterans Affairs Salt Lake City Health Care System; and Vulnerable Veteran Innovative Patient-Aligned-Care-Team (VIP) Initiative, Veterans Affairs Salt Lake City Health Care System, Salt Lake City, Utah.
Background: Syringe services programs (SSPs) are evidence-based harm reduction programs for persons who inject drugs that offer sterile injection equipment and linkages to care including substance use disorder (SUD), medical, and mental health care. Integrating an SSP into a primary care setting may increase engagement and reduce stigma.
Objectives: We sought to describe the purpose, preimplementation, and implementation steps of a primary care-based SSP.
Ann Surg Oncol
August 2025
Division of Breast and Melanoma Surgical Oncology, Department of Surgery, Mayo Clinic, Rochester, MN, USA.