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Objective: Pharmacists care for patients with intracranial bleeding such as those with subarachnoid hemorrhage (SAH) or subdural hematoma (SDH), although these bleeding events are often generically termed "head bleed." This over-simplified term refers to a heterogeneous group of life-threatening intracranial hemorrhages, each with a distinctive etiology and treatment paradigm.
Data Sources: Common intracranial hemorrhage types were reviewed to identify the scope of this narrative review.
Study Selection And Data Abstraction: Relevant studies and guidelines pertinent to the selected topic were considered.
Data Synthesis: Various hemorrhage types such as intracerebral hemorrhage (ICH), subarachnoid hemorrhage (SAH), and SDH fall into the colloquialism of "head bleed." However, these and other hemorrhage types are radiographically distinct and often require different management strategies. Surgical management is helpful in some of these situations (SDH, SAH) and limited in scope for others (ICH). Pharmacotherapy for reversal of coagulopathy and treatment of elevated intracranial pressure may be considered similar across the spectrum of intracranial bleeding pathologies, while other factors such as seizure prophylaxis and blood pressure control depend on the bleeding type.
Relevance To Patient Care And Clinical Practice: Differences in the need for surgical intervention, neurologic monitoring, cerebral perfusion changes, risk of seizure, optimal blood pressure, and other clinical characteristics make each type of intracranial bleeding unique.
Conclusions: Pharmacists should be aware of the differences in surgical and pharmacotherapy strategies among these intracranial hemorrhages to optimize care for this neurocritical care population.
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http://dx.doi.org/10.1177/10600280251358676 | DOI Listing |
Cureus
September 2025
Internal Medicine, NYU Langone Hospital - Long Island, Mineola, USA.
Drug-induced immune thrombocytopenia (DITP) is a rare but life-threatening condition characterized by a sudden and serious drop in the number of platelets from drug-dependent antibodies against platelet glycoproteins. We report the case of a 57-year-old man who developed severe thrombocytopenia and mucocutaneous bleeding following a short course of trimethoprim-sulfamethoxazole (TMP-SMX) for presumed tick-borne disease. The patient experienced bleeding gums, pinpoint rashes, bruising, and extreme fatigue.
View Article and Find Full Text PDFMedicine (Baltimore)
September 2025
Emergency Department, The Second Affiliated Hospital of Shandong First Medical University, Tai'an, China.
Intracerebral hemorrhage (ICH) is a severe and often fatal brain disorder. Despite the recognition of dietary adjustments as a preventive measure, there is a need for well-designed studies to investigate the dietary factors of ICH patients. We employed Mendelian randomization to explore the relationship between 35 dietary factors (exposures) and ICH (outcome).
View Article and Find Full Text PDFNeurocrit Care
September 2025
Department of Paediatrics, Cambridge University, Cambridge, UK.
Background: Low cerebral perfusion pressure (CPP) has previously been identified as a key prognostic marker after pediatric traumatic brain injury (TBI). Cerebrovascular autoregulation supports stabilization of cerebral blood flow within the autoregulation range. Beyond the upper limit of this range, cerebral blood flow increases with increasing CPP, leading to increased risk of intracranial hypertension and blood-brain barrier disruptions.
View Article and Find Full Text PDFNeurosurg Rev
September 2025
Department of Diagnostic and Interventional Neuroradiology, University Hospital Tübingen, Tübingen, Germany.
Purpose: To share our clinical experience with conservative management of isolated spinal arterial aneurysms (ISAs) and to identify clinical scenarios where conservative management may be appropriate, in the context of a literature review.
Methods: We performed a retrospective review of spinal angiograms from two German neuroradiology centers and conducted a systematic literature review of reported ISA cases. We analyzed demographics, clinical presentation, imaging findings, treatments, and outcomes.
J Integr Neurosci
August 2025
Institute of Neuroscience and Third Affiliated Hospital, Zhengzhou University, 450052 Zhengzhou, Henan, China.
Background: Germinal matrix hemorrhage (GMH) is a common complication of premature infants with lifelong neurological consequences. Inflammation-mediated blood-brain barrier (BBB) disruption has been implicated as a main mechanism of secondary brain injury after GMH. The cyclic guanosine monophosphate-adenosine monophosphate synthase (cGAS)-stimulator of interferon genes (STING) pathway plays a crucial role in inflammation, yet its involvement in GMH pathophysiology remains unclear.
View Article and Find Full Text PDF