The Evolving Role of Anti-Müllerian Hormone Measurements in Clinical Practice.

Background: Anti-Müllerian hormone (AMH), a glycoprotein belonging to the transforming growth factor-beta superfamily, plays a pivotal role in reproductive physiology. Initially recognized for its function in male sexual differentiation, AMH has since emerged as a key biomarker with broad clinical applications in both endocrinology and oncology. As research continues to elucidate the physiological roles of AMH, its clinical utility is expanding, necessitating careful assay selection, integration with complementary diagnostic markers, and context-specific interpretation.

Content: A thorough understanding of AMH physiology, assay variability, and clinical interpretation is essential for its effective integration into routine clinical practice. This review provides a concise overview of AMH physiology, explores its diverse clinical applications, examines the evolution and limitations of AMH assays, and presents a comparative analysis of commercially available AMH assays commonly used in clinical laboratories.

Summary: This review highlights the increasing clinical relevance of AMH testing in laboratory medicine, focusing on its expanding applications and the practical analytical considerations essential for accurate interpretation and optimal utilization.